Structure analysis and insight into hydrogen bond and van der waals interactions of etoricoxib cocrystals and cocrystal solvate

Y Wang, L Wang, F Zhang, N Wang, Y Gao… - Journal of Molecular …, 2022 - Elsevier
Etoricoxib (ETR) is a non-ionizable BCS class II drug with no typical hydrogen bond donors
and low solubility in water. Cocrystal was proved to be a good strategy to improve …

Can we exchange water in a hydrate structure: a case study of etoricoxib

S Mittapalli, G Bolla, S Perumalla, A Nangia - CrystEngComm, 2016 - pubs.rsc.org
Novel crystalline forms of etoricoxib (ETR) with pharmaceutically acceptable coformers
(generally regarded as safe, GRAS), such as glutaric acid (1: 1), adipic acid (2: 1), suberic …

Confirmation of more stable polymorphic form of etoricoxib at room temperature

T Zhang, L Wang, Y Bao, Q Yang, L Zhou, H Hao… - Journal of …, 2018 - Elsevier
Polymorphic forms of etoricoxib have been reported in the literature, and form I was
considered to be the most stable one. However, in this work, it was found that form I and form …

Understanding the role of solvent polarity in the molecular self-assembly process of etoricoxib solvates

F Zhang, L Wang, W Fang, Y Liu, P Shi… - Crystal Growth & …, 2020 - ACS Publications
In this paper, a comprehensive study of the solid and solution chemistry of etoricoxib (ETR)
was conducted through the combined experimental identification and theoretical calculation …

Molecular Structural, Hydrogen Bonding Interactions, and Chemical Reactivity Studies of Ezetimibe-L-Proline Cocrystal Using Spectroscopic and Quantum Chemical …

P Prajapati, J Pandey, P Tandon, K Sinha… - Frontiers in …, 2022 - frontiersin.org
Ezetimibe (EZT) being an anticholesterol drug is frequently used for the reduction of
elevated blood cholesterol levels. With the purpose of improving the physicochemical …

Celecoxib sodium salt: engineering crystal forms for performance

JF Remenar, MD Tawa, ML Peterson, Ö Almarsson… - …, 2011 - pubs.rsc.org
Crystalline hydrates and propylene glycol solvates of celecoxib sodium salt (Cel-Na) were
prepared and characterized with the aim of improving oral drug absorption by breaking up …

New cocrystals of ezetimibe with L-proline and imidazole

MR Shimpi, SL Childs, D Boström, SP Velaga - CrystEngComm, 2014 - pubs.rsc.org
The objectives of the study were to screen and prepare cocrystals of anti-cholesterol drug
ezetimibe (EZT) with the aim of increasing its solubility and dissolution rate. Thermodynamic …

Isostructurality in six celecoxib co-crystals introduced by solvent inclusion

X Wang, Q Zhang, L Jiang, Y Xu, X Mei - CrystEngComm, 2014 - pubs.rsc.org
Three co-crystals of celecoxib (CEL) and bipyridine derivatives were synthesized based on
the synthon design approach and structurally characterized. The resulting two-component …

Solubility advantage of tenoxicam phenolic cocrystals compared to salts

G Bolla, P Sanphui, A Nangia - Crystal growth & design, 2013 - ACS Publications
Tenoxicam (TNX) belongs to the oxicam family of drugs popularly known as nonsteroidal
anti-inflammatory drugs (NSAIDs). Its therapeutic action as a drug is limited by poor aqueous …

Screening, Synthesis, and Characterization of a More Rapidly Dissolving Celecoxib Crystal Form

A O'Sullivan, E Spoletti, SA Ross, M Lusi… - ACS …, 2024 - ACS Publications
The prevalence of poor solubility in active pharmaceutical ingredients (APIs) such as
celecoxib (CEL) is a major bottleneck in the pharmaceutical industry, leading to a low …