[HTML][HTML] The placental exposome, placental epigenetic adaptations and lifelong cardio-metabolic health
The placental exposome represents the sum of all placental exposures, and through its
influence on placental function can affect an individual's susceptibility to cardio-metabolic …
influence on placental function can affect an individual's susceptibility to cardio-metabolic …
The dysfunctional placenta epigenome: causes and consequences
SA Lee, C Ding - Epigenomics, 2012 - Taylor & Francis
The placenta is a fetal–maternal endocrine organ responsible for ensuring proper fetal
development throughout pregnancy. Adverse insults to the intrauterine environment often …
development throughout pregnancy. Adverse insults to the intrauterine environment often …
[HTML][HTML] Morphologic and molecular changes in the placenta: what we can learn from environmental exposures
LA Vrooman, F Xin, MS Bartolomei - Fertility and sterility, 2016 - Elsevier
In mammals, the extraembryonic tissues, which include the placenta, are crucial for
embryonic development and growth. Because the placenta is no longer needed for …
embryonic development and growth. Because the placenta is no longer needed for …
Placental origins of chronic disease
Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …
events during their intrauterine phase of development. Biologically this should not be …
[HTML][HTML] Paternal epigenetic influences on placental health and their impacts on offspring development and disease
SS Bhadsavle, MC Golding - Frontiers in Genetics, 2022 - frontiersin.org
Our efforts to understand the developmental origins of birth defects and disease have
primarily focused on maternal exposures and intrauterine stressors. Recently, research into …
primarily focused on maternal exposures and intrauterine stressors. Recently, research into …
Molecular pathways in placental-fetal development and disruption
The first trimester of pregnancy ranks high in priority when minimizing harmful exposures,
given the wide-ranging types of organogenesis occurring between 4-and 12-weeks' …
given the wide-ranging types of organogenesis occurring between 4-and 12-weeks' …
Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism
Compelling epidemiological and animal experimental data demonstrate that
cardiometabolic and neuropsychiatric diseases originate in a suboptimal intrauterine …
cardiometabolic and neuropsychiatric diseases originate in a suboptimal intrauterine …
The impact of prenatal insults on the human placental epigenome: A systematic review
The placenta is the first human organ to reach full development during pregnancy. It serves
as a barrier but also as an interchange surface. Epigenetic changes observed in placental …
as a barrier but also as an interchange surface. Epigenetic changes observed in placental …
The ever growing complexity of placental epigenetics–role in adverse pregnancy outcomes and fetal programming
B Novakovic, R Saffery - Placenta, 2012 - Elsevier
As the primary interface between maternal and fetal circulations, the placenta is subject to a
myriad of environmental exposures with the capacity to alter placental function and fetal …
myriad of environmental exposures with the capacity to alter placental function and fetal …
Sex-specific placental responses in fetal development
CS Rosenfeld - Endocrinology, 2015 - academic.oup.com
The placenta is an ephemeral but critical organ for the survival of all eutherian mammals
and marsupials. It is the primary messenger system between the mother and fetus, where …
and marsupials. It is the primary messenger system between the mother and fetus, where …