Understanding the genetic factors of diabetes is essential for addressing the global increase
in type 2 diabetes. HNF1A mutations cause a monogenic form of diabetes called maturity …

Mutations in the genes encoding hepatocyte nuclear factor (HNF) 1α and HNF4α cause a
monogenic form of diabetes mellitus known as maturity-onset diabetes of the young …

Mutations in HNF1A cause Maturity Onset Diabetes of the Young (HNF1A-MODY). To
understand mechanisms of β-cell dysfunction, we generated stem cell-derived pancreatic …

TYPE 2 diabetes mellitus is a heterogenous group of disorders characterized by a high
blood glucose level. Pancreatic b-cell dysfunction and insulin resistance of target tissues …

Human monogenic diabetes, caused by mutations in genes involved in beta cell
development and function, has been a challenge to study because multiple mouse models …

Hepatocyte nuclear factor 1-α (HNF-1α) is a homeodomain transcription factor expressed in
a variety of tissues (including liver and pancreas) that regulates a wide range of genes …

Maturity-onset diabetes of the young (MODY) is a rare subtype of type 2 diabetes that is
characterized by autosomal-dominant inheritance and can be caused by mutations in …

Mutations in the transcription factor hepatocyte nuclear factor-1α (HNF-1α) cause maturity-
onset diabetes of the young 3, a severe form of diabetes characterized by pancreaticβ-cell …

Diabetes, a disease characterized by hyperglycemia, has a serious impact on the lives and
families of patients as well as on society. Diabetes is a group of highly heterogeneous …

Heterozygous HNF1A gene mutations can cause maturity onset diabetes of the young 3
(MODY3), characterized by insulin secretion defects. However, specific mechanisms of …