Glucose-activatable insulin delivery with charge-conversional polyelectrolyte multilayers for diabetes care
Y Yang, X Wang, X Yuan, Q Zhu, S Chen… - … in Bioengineering and …, 2022 - frontiersin.org
One of the most effective treatments for diabetes is to design a glucose-regulated insulin
(INS) delivery system that could adjust the INS release time and rate to reduce diabetes …
(INS) delivery system that could adjust the INS release time and rate to reduce diabetes …
Engineered insulin-polycation complexes for glucose-responsive delivery with high insulin loading
LR Volpatti, DM Burns, A Basu, R Langer… - Journal of Controlled …, 2021 - Elsevier
Glucose-responsive insulin delivery systems have the potential to improve quality of life for
individuals with diabetes by improving blood sugar control and limiting the risk of …
individuals with diabetes by improving blood sugar control and limiting the risk of …
Microneedle-array patch with pH-sensitive formulation for glucose-responsive insulin delivery
FQ Luo, G Chen, W Xu, D Zhou, JX Li, YC Huang, R Lin… - Nano Research, 2021 - Springer
Glucose-responsive insulin delivery systems show great promise to improve therapeutic
outcomes and quality of life for people with diabetes. Herein, a new microneedle-array patch …
outcomes and quality of life for people with diabetes. Herein, a new microneedle-array patch …
Erythrocyte‐membrane‐camouflaged nanoplatform for intravenous glucose‐responsive insulin delivery
An artificial “closed‐loop” system that mimics the glucose‐responsive insulin secretion of
pancreas β‐cells can potentially improve the treatment efficacy for diabetes. Herein, a lipid …
pancreas β‐cells can potentially improve the treatment efficacy for diabetes. Herein, a lipid …
Glucose and H2O2 Dual-Responsive Nanocomplex Grafted with Insulin Prodrug for Blood Glucose Regulation
X Xu, Y Ran, C Huang, Z Yin - Biomacromolecules, 2022 - ACS Publications
Although “closed-loop” smart insulin delivery systems have been extensively investigated,
the majority of them suffer from low insulin loading efficiency and slow glucose response …
the majority of them suffer from low insulin loading efficiency and slow glucose response …
Fabrication of biobased polyelectrolyte capsules and their application for glucose-triggered insulin delivery
D Shi, M Ran, L Zhang, H Huang, X Li… - … applied materials & …, 2016 - ACS Publications
To enhance the glucose sensitivity and self-regulated release of insulin, biobased capsules
with glucose-responsive and competitive properties were fabricated based on poly (γ …
with glucose-responsive and competitive properties were fabricated based on poly (γ …
Hypoxia and H2O2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery
A glucose-responsive closed-loop insulin delivery system mimicking pancreas activity
without long-term side effect has the potential to improve diabetic patients' health and quality …
without long-term side effect has the potential to improve diabetic patients' health and quality …
Glucose- and H2O2-Responsive Polymeric Vesicles Integrated with Microneedle Patches for Glucose-Sensitive Transcutaneous Delivery of Insulin in Diabetic Rats
Z Tong, J Zhou, J Zhong, Q Tang, Z Lei… - … applied materials & …, 2018 - ACS Publications
Herein, a dual-responsive insulin delivery device by integrating glucose-and H2O2-
responsive polymeric vesicles (PVs) with transcutaneous microneedles (MNs) has been …
responsive polymeric vesicles (PVs) with transcutaneous microneedles (MNs) has been …
Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs
Glucose-responsive insulin delivery systems with robust responsiveness that has been
validated in animal models, especially in large animal models, remain elusive. Here, we …
validated in animal models, especially in large animal models, remain elusive. Here, we …
The influence of arrangement sequence on the glucose-responsive controlled release profiles of insulin-incorporated LbL films
Insulin, glucose oxidase and positively charged star polymers were incorporated into
multilayer films by the layer-by-layer (LbL) assembly method. It is interesting to find that the …
multilayer films by the layer-by-layer (LbL) assembly method. It is interesting to find that the …
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