Objectives To investigate the timeframe prior to symptom onset when cortico-basal ganglia
white matter (white matter) loss begins in premanifest Huntington's disease (preHD), and …

Although much prior work has focused on the basal ganglia and cortical pathology that
defines Huntington's disease (HD), recent studies have also begun to characterize cerebral …

As one of the clinical triad in Huntington's disease (HD), cognitive impairment has not been
widely accepted as a disease stage indicator in HD literature. This work aims to study …

Huntington disease (HD) is caused by an abnormally expanded cytosine–adenine–guanine
(CAG) trinucleotide repeat in the HTT gene. Age and CAG-expansion number are related to …

Objective To quantify 18-month changes in white matter microstructure in premanifest (pre-
HD) and symptomatic Huntington's disease (symp-HD). To investigate baseline clinical …

Background Whole‐brain longitudinal diffusion studies are crucial to examine changes in
structural connectivity in neurodegeneration. Here, we investigated the longitudinal …

ABSTRACT BACKGROUND AND PURPOSE Early white matter (WM) changes and cortical
atrophy in Huntington's disease (HD) are often evident before disease onset and extend …

Objectives: To investigate the function–structure relationship of white matter within different
stages of Huntington's disease (HD) using diffusion tensor imaging (DTI). Experimental …

Background and objective Controversy exists regarding the feasibility of preventive clinical
trials in prodromal Huntington disease (HD). A primary limitation is a lack of outcome …

Objective Huntington's disease (HD) is a monogenic, fully penetrant neurodegenerative
disorder, providing an ideal model for understanding brain changes occurring in the years …