Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design
Y Liu, L Wang, L Zhao, Y Zhang - Natural Product Reports, 2022 - pubs.rsc.org
Covering up to 2022 Gossypol is a polyphenolic compound isolated from cottonseed. There
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …
Recent advances in gossypol derivatives and analogs: a chemistry and biology view
Y Lu, J Li, CE Dong, J Huang, HB Zhou… - Future Medicinal …, 2017 - Future Science
Gossypol as a natural occurring polyphenol has been studied in a wide range of therapeutic
contexts for a long time. The chemical modifications on gossypol were limited due to the …
contexts for a long time. The chemical modifications on gossypol were limited due to the …
[HTML][HTML] Gossypol and its natural derivatives: multitargeted phytochemicals as potential drug candidates for oncologic diseases
Despite the vast amounts of research and remarkable discoveries that have been made in
recent decades, cancer remains a leading cause of death and a major public health concern …
recent decades, cancer remains a leading cause of death and a major public health concern …
Reaction chemistry of gossypol and its derivatives
JA Kenar - Journal of the American Oil Chemists' Society, 2006 - Wiley Online Library
Gossypol, a complex polyphenolic compound, is a naturally occurring highly colored yellow
pigment found in the small intercellular pigment glands in the leaves, stems, roots, and seed …
pigment found in the small intercellular pigment glands in the leaves, stems, roots, and seed …
Gossypol-a polyphenolic compound from cotton plant
X Wang, CP Howell, F Chen, J Yin, Y Jiang - Advances in food and nutrition …, 2009 - Elsevier
Abstract Gossypol (C 30 H 30 O 8) is a polyphenolic compound derived from the cotton plant
(genus Gossypium, family Malvaceae). The presence of six phenolic hydroxyl groups and …
(genus Gossypium, family Malvaceae). The presence of six phenolic hydroxyl groups and …
Natural product gossypol and its derivatives in precision cancer medicine
Gossypol, a natural product extracted from the seed, roots, and stem of cotton, was initially
used as a male contraceptive but was subsequently investigated as a novel antitumor agent …
used as a male contraceptive but was subsequently investigated as a novel antitumor agent …
Structure-activity studies on gossypol in tumor cell lines
MD Shelley, L Hartley, PW Groundwater… - Anti-cancer …, 2000 - journals.lww.com
Abstract Gossypol [(2, 2′-binaphthalene)-8, 8′-dicarboxaldehyde-1, 1′, 6, 6′, 7, 7′-
hexahydroxy-5, 5′-diisopropyl-3, 3′-dimethyl] 1a is a naturally occurring compound …
hexahydroxy-5, 5′-diisopropyl-3, 3′-dimethyl] 1a is a naturally occurring compound …
Design and synthesis of a gossypol derivative with improved antitumor activities
A novel chemical process has been devised for the synthesis of a new derivative of
gossypol, 6, 7, 6′, 7′‐tetrahydroxy‐5, 5′‐diisopropyl‐3, 3′‐dimethyl‐[2, 2'] …
gossypol, 6, 7, 6′, 7′‐tetrahydroxy‐5, 5′‐diisopropyl‐3, 3′‐dimethyl‐[2, 2'] …
Developing gossypol derivatives with enhanced antitumor activity
XS Liang, AJ Rogers, CL Webber, TJ Ormsby… - Investigational new …, 1995 - Springer
Preclinical and clinical studies have pointed to the antitumor potential of the naturally
occurring polyphenolic binaphthyl dialdehyde, gossypol, as well as its purified (−,+) …
occurring polyphenolic binaphthyl dialdehyde, gossypol, as well as its purified (−,+) …
Cytotoxicity of enantiomers of gossypol Schiff's bases and optical stability of gossypolone
VT Dao, MK Dowd, MT Martin, C Gaspard… - European journal of …, 2004 - Elsevier
Optical Schiff's bases of gossypol were prepared with chiral gossypol and ethylamine. As
has been similarly observed among the gossypol enantiomers, the (–)-gossypol ethylimine …
has been similarly observed among the gossypol enantiomers, the (–)-gossypol ethylimine …