Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

Bone is an active tissue, being constantly renewed in healthy individuals with participation of
the immune system to a large extent. Any imbalance between the processes of bone …

We summarize research approaches and findings on bone healing and regeneration that
were presented at a workshop at the 60th annual meeting of the Orthopedic Research …

Key events occurring during the bone healing include well-orchestrated and complex
interactions between immune cells, multipotential stromal cells (MSCs), osteoblasts and …

Bone is a self-regenerative tissue that can repair small defects and fractures. In large
defects, bone tissue is unable to provide nutrients and oxygen for repair, and autologous …

Single trauma injuries or isolated fractures are often manageable and generally heal without
complications. In contrast, high-energy trauma results in multi/poly-trauma injury patterns …

The immune system, best known as the first line of defense against invading pathogens, is
integral to tissue development, homeostasis, and wound repair. In recent years, there has …

The ability of articular cartilage to repair itself is limited because it lacks blood vessels,
nerves, and lymph tissue. Once damaged, it can lead to joint swelling and pain, accelerating …

Impaired bone healing occurs in 5–10% of cases following injury, leading to a significant
economic and clinical impact. While an inflammatory response upon injury is necessary to …

Tissue engineering strategies for treating bone loss to date have largely focused on
targeting stem cells or vascularization. Immune cells, including macrophages and T cells …