Abstract Metastatic Breast Cancer has a poor 25% survival rate and currently there are no
clinical therapeutics which target metastasis.'Migrastatics' are a new drug class which target …

Despite efforts to discover the cellular pathways regulating breast cancer metastasis, little is
known as to how prolactin (PRL) cooperates with extracellular environment and cytoskeletal …

Background The serine/threonine kinase PAK1 is an important regulator of cell motility. Both
PAK1 and the hormone/cytokine prolactin (PRL) have been implicated in breast cancer cell …

Stimulation of growth factor signaling has been implicated in the development of invasive
phenotype and p21-activated kinase (PAK1) activation in human breast epithelial cancer …

BReast tumor Kinase (BRK) also known as protein kinase 6 (PTK6) is a nonreceptor tyrosine
kinase overexpressed in the majority of human breast tumors. Although some studies have …

Cytoskeletal remodeling is critical for cell adhesion, spreading, and motility. p21-activated
kinase (PAK), an effector molecule of the Rho GTPases Rac and Cdc42, has been …

The p21-activated serine-threonine kinase (PAK1) is activated by small GTPase-dependent
and-independent mechanisms and regulates cell motility. Both PAK1 and the hormone …

Introduction The adhesion protein junctional adhesion molecule-A (JAM-A) regulates
epithelial cell morphology and migration, and its over-expression has recently been linked …

Cell motility requires the spatial and temporal coordination of forces in the actomyosin
cytoskeleton with extracellular adhesion. The biochemical mechanism that coordinates …

Summary The phosphatidylinositol 3-kinase (PI3K) signaling pathway is frequently
deregulated in cancer. Downstream of PI3K, Akt1 and Akt2 have opposing roles in breast …