Delayed and often impaired wound healing in the elderly presents major medical and
socioeconomic challenges. A comprehensive understanding of the cellular/molecular …

Aged skin heals wounds poorly, increasing susceptibility to infections. Restoring
homeostasis after wounding requires the coordinated actions of epidermal and immune …

Wound healing is a well-organized dynamic process involving coordinated consecutive
phases: homeostasis, inflammation, proliferation and resolution. Fibroblasts play major roles …

Simple Summary The biology of cellular senescence has broad implications for the fields of
aging, tissue and wound repair, tumor biology, and development. Cellular senescence is a …

Significance: Chronic wounds, such as diabetic foot ulcers, venous stasis ulcers, and
pressure ulcers affect millions of Americans each year, and disproportionately afflict our …

An effective healing response is critical to promote and ensure healthy aging. Major
discoveries in both fields—repair and aging—have led to a better understanding of the …

Cellular senescence is a fundamental stress response that restrains tumour formation. Yet,
senescence cells are also present in non-cancerous states, accumulating exponentially with …

Wound healing is a complex process that involves the coordinated actions of many different
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …

Cutaneous wound healing is a complex process encompassing a number of overlapping
events including leukocyte recruitment, matrix deposition, epithelialization, and ultimately …

Wound healing is a complex, dynamic process supported by a myriad of cellular events that
must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound …