Intervertebral disc degeneration (IDD) is highly ubiquitous in the aged population and is an
essential factor for low back pain and spinal disability. Because of the association between …

Antiaging protein Klotho exhibits impressive properties of anti‐inflammation, however is
declined early after intervertebral disc injury, making Klotho restoration an attractive strategy …

Background Intervertebral disk (IVD) degeneration is the most common cause of lower back
pain. Inhibiting inflammation is a key strategy for delaying IVD degeneration. Tacrolimus …

Nucleus pulposus (NP) cell (NPC) senescence is one of the main causes of intervertebral
disc degeneration (IVDD). However, the underlying mechanism of NPC senescence is still …

Abstract Coenzyme Q10 (Co-Q10) is extraordinarily popular and has been used in abundant
interventions as an antioxidant reagent that participates in numerous oxidation reactions …

Intervertebral disc (IVD) degeneration (IVDD) is a characteristic of the dominating
pathological processes of nucleus pulposus (NP) cell senescence, abnormal synthesis and …

Introduction Over-activation of oxidative stress due to impaired antioxidant functions in
nucleus pulpous (NP) has been identified as a key factor contributing to intervertebral disc …

Intervertebral disk degeneration (IVDD) is the major cause of low back pain. Alpha-
ketoglutaric acid (α-KG), an important intermediate in energy metabolism, has various …

Intervertebral disc degeneration is characterized by an imbalance between catabolic and
anabolic signaling, with an increase in catabolic cytokines particularly IL‐1β, a key regulator …

Intervertebral disc degeneration (IDD) is a chronic skeletal muscle degenerative disease,
which is considered the main cause of low back pain. It seriously affects the quality of life of …