Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer's disease
W Liu, J Li, M Yang, X Ke, Y Dai, H Lin, S Wang… - Alzheimer's research & …, 2022 - Springer
Background The degeneration of the cholinergic circuit from the basal forebrain to the
hippocampus contributes to memory loss in patients suffering from Alzheimer's disease …
hippocampus contributes to memory loss in patients suffering from Alzheimer's disease …
Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease
JS Aucoin, P Jiang, N Aznavour, XK Tong, M Buttini… - Neuroscience, 2005 - Elsevier
Alzheimer's disease (AD) is characterized by increases in amyloid-β (Aβ) peptides,
neurofibrillary tangles, oxidative stress and cholinergic deficits. However, the selectivity of …
neurofibrillary tangles, oxidative stress and cholinergic deficits. However, the selectivity of …
Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning
P Mohapel, G Leanza, M Kokaia, O Lindvall - Neurobiology of aging, 2005 - Elsevier
Hippocampus-mediated learning enhances neurogenesis in the adult dentate gyrus (DG),
and this process has been suggested to be involved in memory formation. The hippocampus …
and this process has been suggested to be involved in memory formation. The hippocampus …
Cholinergic neurodegeneration in Alzheimer disease mouse models
A Shekari, M Fahnestock - Handbook of clinical neurology, 2021 - Elsevier
Cholinergic signaling is critical for cognitive function. The basal forebrain is the major
cholinergic output of the central nervous system. Degeneration of basal forebrain cholinergic …
cholinergic output of the central nervous system. Degeneration of basal forebrain cholinergic …
Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease
YI Francis, M Fà, H Ashraf, H Zhang… - Journal of …, 2009 - content.iospress.com
Epigenetic mechanisms such as post-translational histone modifications are increasingly
recognized for their contribution to gene activation and silencing in the brain. Histone …
recognized for their contribution to gene activation and silencing in the brain. Histone …
Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation
R Velazquez, E Ferreira, S Knowles, C Fux… - Aging cell, 2019 - Wiley Online Library
Currently, there are no effective therapies to ameliorate the pathological progression of
Alzheimer's disease (AD). Evidence suggests that environmental factors may contribute to …
Alzheimer's disease (AD). Evidence suggests that environmental factors may contribute to …
Cholinergic strategies for Alzheimer's disease
Alzheimer's disease is a devastating degenerative disorder of the central nervous system
that results in gradual deterioration of cognitive function and severe alteration of personality …
that results in gradual deterioration of cognitive function and severe alteration of personality …
Choline Supplementation Ameliorates Behavioral Deficits and Alzheimer's Disease‐Like Pathology in Transgenic APP/PS1 Mice
Y Wang, X Guan, X Chen, Y Cai, Y Ma… - Molecular nutrition & …, 2019 - Wiley Online Library
Scope Alzheimer's disease (AD) is a detrimental neurodegenerative disease and has no
known effective treatment. The essential nutrient choline potentially plays an important role …
known effective treatment. The essential nutrient choline potentially plays an important role …
Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease
T Watanabe, N Yamagata, K Takasaki, K Sano… - Brain research, 2009 - Elsevier
Acetylcholine (ACh) release is one of the key factors in memory mechanisms. To clarify
whether beta-amyloid (Aβ) induces a disturbance of the cholinergic system leading to …
whether beta-amyloid (Aβ) induces a disturbance of the cholinergic system leading to …
Cholinergic differentiation of human neuroblastoma SH-SY5Y cell line and its potential use as an in vitro model for Alzheimer's disease studies
LM de Medeiros, MA De Bastiani, EP Rico… - Molecular …, 2019 - Springer
Cholinergic transmission is critical to high-order brain functions such as memory, learning,
and attention. Alzheimer's disease (AD) is characterized by cognitive decline associated …
and attention. Alzheimer's disease (AD) is characterized by cognitive decline associated …