Background The degeneration of the cholinergic circuit from the basal forebrain to the
hippocampus contributes to memory loss in patients suffering from Alzheimer's disease …

Alzheimer's disease (AD) is characterized by increases in amyloid-β (Aβ) peptides,
neurofibrillary tangles, oxidative stress and cholinergic deficits. However, the selectivity of …

Hippocampus-mediated learning enhances neurogenesis in the adult dentate gyrus (DG),
and this process has been suggested to be involved in memory formation. The hippocampus …

Cholinergic signaling is critical for cognitive function. The basal forebrain is the major
cholinergic output of the central nervous system. Degeneration of basal forebrain cholinergic …

Epigenetic mechanisms such as post-translational histone modifications are increasingly
recognized for their contribution to gene activation and silencing in the brain. Histone …

Currently, there are no effective therapies to ameliorate the pathological progression of
Alzheimer's disease (AD). Evidence suggests that environmental factors may contribute to …

Alzheimer's disease is a devastating degenerative disorder of the central nervous system
that results in gradual deterioration of cognitive function and severe alteration of personality …

Scope Alzheimer's disease (AD) is a detrimental neurodegenerative disease and has no
known effective treatment. The essential nutrient choline potentially plays an important role …

Acetylcholine (ACh) release is one of the key factors in memory mechanisms. To clarify
whether beta-amyloid (Aβ) induces a disturbance of the cholinergic system leading to …

Cholinergic transmission is critical to high-order brain functions such as memory, learning,
and attention. Alzheimer's disease (AD) is characterized by cognitive decline associated …