G protein‐coupled receptors (GPCRs) are the most common and important drug targets.
However,> 70% of GPCRs are undruggable or difficult to target using conventional chemical …

Small activating RNAs (saRNAs) are small double-stranded RNAs that could mediate the
target-specific gene expression by targeting selected sequences in gene promoters at both …

Background: RNA is increasingly recognized as a powerful molecule that can be used to
control gene expression. Sophisticated, well-engineered RNA-based regulators are being …

Small activating RNAs (saRNAs) are short double-stranded oligonucleotides that selectively
increase gene transcription. Here, we describe the development of an saRNA that …

RNA activation (RNAa) allows specific gene upregulation mediated by a small activating
RNA (saRNA). Harnessing this process would help in developing novel therapeutics for …

Small double-strand RNA (dsRNA) molecules can activate endogenous genes via an RNA-
based promoter targeting mechanism. RNA activation (RNAa) is an evolutionarily conserved …

RNA activation is a promising discovery that promoter-targeted double-stranded small
RNAs, termed small activating RNAs (saRNAs), can induce gene expression, which …

RNA activation (RNAa) is a novel mechanism in which short RNA duplexes, referred to as
small activating RNAs (saRNAs), enable sequence-specific gene activation capable of …

The high vulnerability of mRNA necessitates the manufacture of delivery vehicles to afford
adequate protection in the biological milieu. Here, mRNA was complexed with a mixture of …

Non-small-cell lung cancer (NSCLC) is the second most diagnosed type of malignancy and
the first cause of cancer death worldwide. Despite recent advances, the treatment of choice …