Tumor formation and progression have been much of a study over the last two centuries.
Recent studies have seen different developments for the early diagnosis and treatment of …

Cysteine cathepsins (CTS), being involved in both physiological and pathological
processes, play an important role in the human body. During the last 30 years, it has been …

S-Nitrosoglutathione (GSNO) is an endogenous transnitrosation donor involved in S-
nitrosation of a variety of cellular proteins, thereby regulating diverse protein functions …

Cysteine cathepsins are a family of lysosomal proteases that are often upregulated in
various human cancers, and have been implicated in distinct tumorigenic processes such as …

Cysteine cathepsins play an important role in many (patho) physiological conditions. Among
them, cathepsins L, S, K and B are subjects of several drug discovery programs. Besides …

Cysteine cathepsins have been known for a long time to play an important role in cancer
progression and metastasis. Several studies have proposed the concept of anti-cathepsin …

Targeting thioredoxin reductase (TXNRD) with low-weight molecules is emerging as a high-
efficacy anti-cancer strategy in chemotherapy. Sanguinarine has been reported to inhibit the …

Abstract Background Cathepsins K, L, and S are cysteine proteases upregulated in cancer
and proteolyze extracellular matrix to facilitate metastasis, but difficulty distinguishing …

Transnitrosylation and denitrosylation are emerging as key post-translational modification
events in regulating both normal physiology and a wide spectrum of human diseases …

The oxidation chemistry of thiols and disulfides of biologic relevance is described. The
review focuses on the interaction and kinetics of hydrogen peroxide with low-molecular …