Genetic variants associated with longitudinal changes in brain structure across the lifespan
Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Common risk factors for psychiatric and other brain disorders are likely to converge on
biological pathways influencing the development and maintenance of brain structure and …
biological pathways influencing the development and maintenance of brain structure and …
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
Cortical thickness, surface area and volumes vary with age and cognitive function, and in
neurological and psychiatric diseases. Here we report heritability, genetic correlations and …
neurological and psychiatric diseases. Here we report heritability, genetic correlations and …
Voxelwise genome-wide association study (vGWAS)
The structure of the human brain is highly heritable, and is thought to be influenced by many
common genetic variants, many of which are currently unknown. Recent advances in …
common genetic variants, many of which are currently unknown. Recent advances in …
Age-related differences in brain morphology and the modifiers in middle-aged and older adults
Brain structural morphology differs with age. This study examined age-differences in surface-
based morphometric measures of cortical thickness, volume, and surface area in a well …
based morphometric measures of cortical thickness, volume, and surface area in a well …
Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive …
Volumetric variations of the human brain are heritable and are associated with many brain-
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
Genetic architecture of subcortical brain structures in 38,851 individuals
Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens …
We identified common genetic variation related to the volumes of the nucleus accumbens …
[HTML][HTML] Differential aging analysis in human cerebral cortex identifies variants in TMEM106B and GRN that regulate aging phenotypes
H Rhinn, A Abeliovich - Cell systems, 2017 - cell.com
Human age-associated traits, such as cognitive decline, can be highly variable across the
population, with some individuals exhibiting traits that are not expected at a given …
population, with some individuals exhibiting traits that are not expected at a given …
Voxelwise gene-wide association study (vGeneWAS): multivariate gene-based association testing in 731 elderly subjects
Imaging traits provide a powerful and biologically relevant substrate to examine the
influence of genetics on the brain. Interest in genome-wide, brain-wide search for influential …
influence of genetics on the brain. Interest in genome-wide, brain-wide search for influential …
Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes
Our understanding of the genetics of the human cerebral cortex is limited both in terms of the
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …