Reports of sex differences in the neurobiology of memory formation are becoming more
prevalent. Despite this, much remains unknown about the role of sex in this process. We …

Memory formation requires coordinated control of gene expression, protein synthesis, and
ubiquitin–proteasome system (UPS)-mediated protein degradation. The catalytic component …

The ubiquitin proteasome system (UPS) is a primary mechanism through which proteins are
degraded in cells. UPS activity in the dorsal hippocampus (DH) is necessary for multiple …

CaMKII and Protein Kinase A (PKA) are thought to be critical for synaptic plasticity and
memory formation through their regulation of protein synthesis. Consistent with this …

Background Posttranslational histone modifications play a critical role in the regulation of
gene transcription underlying synaptic plasticity and memory formation. One such epigenetic …

Dynamic control of protein degradation via the ubiquitin proteasome system (UPS) is
thought to play a crucial role in neuronal function and synaptic plasticity. The proteasome …

Aging is marked by an accumulation of damaged and modified brain proteins, and the
ubiquitin-proteasome system (UPS) is important for cellular protein degradation. Recent …

Background Memory consolidation, reconsolidation, and extinction have been shown to
require new gene expression. Poly ADP-ribosylation mediated by poly (ADP-ribose) …

Chromatin remodeling through histone posttranslational modifications (PTMs) and DNA
methylation has recently been implicated in cognitive functions, but the mechanisms …

It has become increasingly evident that protein degradation via the ubiquitin proteasome
system plays a fundamental role in the development, maintenance and remodeling of …