We have previously shown that the heteromer composed by the dopamine D3 receptor
(D3R) and the nicotinic acetylcholine receptor (nAChR)(D3R-nAChR heteromer) is …

Activation of nicotinic acetylcholine receptors (nAChR) promotes the morphological
remodeling of cultured dopamine (DA) neurons, an effect requiring functional DA D3 …

The dopamine (DA) D3 receptor (D3R) plays a pivotal role in the control of several functions,
including motor activity, rewarding and motivating behavior and several aspects of cognitive …

Midbrain dopamine (DA) neurons are considered a critical substrate for the reinforcing and
sensitizing effects of nicotine and tobacco dependence. While the role of the α4 and β2 …

Although long-term exposure to nicotine is highly addictive, one beneficial consequence of
chronic tobacco use is a reduced risk for Parkinson's disease. Of interest, these effects both …

The role of dopamine D2 and D3 receptors (D2R/D3R), located on midbrain dopaminergic
(DA) neurons, in the regulation of DA synthesis and release and in DA neuron homeostasis …

Dopamine receptors exhibit tissue‐and cell type‐specific expression that is modulated
during development, aging and in diseases such as Parkinson's. The molecular …

Dopaminergic neurons express an heteromer composed of the dopamine D3 receptor and
the α4-β2 nicotinic acetylcholine receptor, the D3R-nAChR heteromer, activated by both …

In this paper, we designed, synthesized and tested a small set of three new derivatives
potentially targeting the D3R-nAChR heteromer, a receptor complex recently identified and …

Nicotine, acting on nicotinic acetylcholine receptors (nAChRs) expressed at pre‐synaptic
dopaminergic terminals, has been shown to stimulate the release of dopamine in the …