Compared with other research fields, both microbiome and metabolomics data are
complicated and have some unique characteristics, respectively. Thus, choosing an …

Motivation Microbiome–metabolome association studies have experienced exponential
growth for an in-depth understanding of the impact of microbiota on human health over the …

In this chapter, we first introduce and discuss the themes and statistical hypotheses in
human microbiome studies in Sect. 3.1. Then, we overview the classic statistical methods …

In the post-genomic era, metabolomics (or metabonomics), genomics, transcriptomics and
proteomics have become important tools in systems biology. In metabolome analysis field …

The advancement of DNA/RNA, proteins, and metabolite analytical platforms, combined with
increased computing technologies, has transformed the field of microbial community …

Metabolomics is the comprehensive study of small molecule metabolites in biological
systems. By assaying and analyzing thousands of metabolites in biological samples, it …

Microbiome is the collection of all microbes that live in and on human body. It plays
important roles in maintaining human health. Microbiome dysbiosis has been shown to be …

Metabolomics as a research field and a set of techniques is to study the entire small
molecules in biological samples. Metabolomics is emerging as a powerful tool generally for …

The demand for understanding the roles genes play in biological systems has steered the
biosciences into the direction the metabolome, as it closely reflects the metabolic activities …

Microbiome research and microbiome data analysis are one of the fast-growing areas in
biomedical and public health research. It is evidenced and catalyzed by publications in …