This work combines microbiology, molecular biology, Next-Generation Sequencing and
system biology approaches to explore the mechanism of antibiotic persistence: a multi-drug …

Recalcitrant infections pose a serious challenge by prolonging antibiotic therapies and
contributing to the spread of antibiotic resistance, thereby threatening the successful …

Microbial drug persistence is a widespread phenomenon in which a subpopulation of
microorganisms is able to survive antimicrobial treatment without acquiring resistance …

Persistence has been linked to treatment failure since its discovery over 70 years ago and
understanding formation, nature and survival of this key antibiotic refractory subpopulation is …

The current antibiotic resistance crisis has led to increased pressure to prioritize strategies to
tackle the issue, with a strong focus being placed on the development of novel …

Bacteria have at their disposal a battery of strategies to withstand antibiotic stress. Among
these, resistance is a well-known mechanism, yet bacteria can also survive antibiotic attack …

Bacterial persistence is a potential cause of antibiotic therapy failure. Antibiotic-tolerant
persisters originate from phenotypic differentiation within a susceptible population, occurring …

Persisters are transiently tolerant variants that allow populations to avoid eradication by
antibiotic treatment. Their antibiotic tolerance is non-genetic, not inheritable and results from …

The application of the prototype antibiotics penicillin and streptomycin to bacterial infection
in the 1940's marked a historic milestone in medicine and heralded a new era of …

Any bacterial population harbors a small number of phenotypic variants that survive
exposure to high concentrations of antibiotic. Importantly, these so-called 'persister cells' …