A series of novel N-alkyl-N-hydroxyl carboximates derived from β-elemene were fortuitously
discovered. Most of them showed more potent anti-proliferative activities than their lead …

Background: Natural products have been an exemplary source of new drugs as they have
served as direct or indirect precursors for many currently available medicines. The natural …

A series of β-elemene monosubstituted ester, carbamate, acylamide, and carbamidine
derivatives were synthesized via intermediates, β-elemene alcohol and β-elemene amine …

Herein, we report the first access of β-elemene derivatives through the SeO2-mediated
oxidation reaction. Several new compounds were isolated through such a one-step reaction …

A series of novel β-elemene isopropanolamine derivatives were synthesized and evaluated
for their antitumor activity. The results indicated that all of the compounds showed stronger …

Malignant brain tumors are aggressive in both children and adults. Despite recent
improvements in diagnostic techniques, therapeutic approaches remain disappointing and …

Elemene has been approved for the treatment of advanced cancer in China, however, it
inhibits cell growth only at high concentrations and is an essential oil with poor water …

Increasing knowledge on the hallmark characteristics of cancer and tumor pharmacology
has promoted the introduction of phytochemicals, such as traditional Chinese medicine …

Natural products are important sources for drug discovery, especially anti-tumor drugs. β-
Elemene, the prominent active ingredient extract from the rhizome of Curcuma wenyujin, is a …

ABSTRACT β-elemene is the sesquiterpene active monomer, as a national second-class
non-cell toxic antitumor drugs which extracted from Zingiberaceae Curcuma rcenyujin …