The mechanisms through which the androgen‐dependent activation of the androgen
receptor (AR) regulates gravid uterine ferroptosis remain unknown. We show that while co …

Women with polycystic ovary syndrome (PCOS) have hyperandrogenism and insulin
resistance and a high risk of miscarriage during pregnancy. Similarly, in rats, maternal …

Iron, as an essential trace element for the organism, is vital for maintaining the organism's
health. Excessive iron can promote reactive oxygen species (ROS) accumulation, thus …

Research question: Does hyperandrogenism affect ovarian granulosa cells (GCs) function
through activation of ferroptosis? Is hyperandrogen-induced ferroptosis regulated by …

The mechanisms that link hyperandrogenism and insulin (INS) resistance (HAIR) to the
increased miscarriage rate in women with polycystic ovary syndrome (PCOS) remain …

Endometriosis is strongly associated with infertility. Several mechanisms have been
reported in an attempt to elucidate the pathophysiological effects that lead to reduced fertility …

Ferroptosis is a novel types of regulated cell death and is widely studied in cancers and
many other diseases in recent years. It is characterized by iron accumulation and intense …

Nuclear factor-E2-related factor 2 (Nrf2) expression in sperm decreases in some
oligospermia patients. However, the mechanism of reduced Nrf2 expression in sperm of …

STUDY QUESTION Does ovarian ferroptosis play an active role in the development of
PCOS? SUMMARY ANSWER Increased ovarian ferroptosis was present in PCOS ovaries …

Ferroptosis is a novel type of regulated cell death driven by iron-dependent lipid
peroxidation, which is distinguished from traditional types of programmed cell death, such as …