Inhaled glucocorticoids (GCs) are drugs widely used as treatment for asthma patients. They
prevent the recruitment and activation of lung immune and inflammatory cells and …

Most patients with asthma are successfully treated with conventional therapy. Nevertheless,
there is a small proportion of asthmatic patients, including present cigarette smokers and …

Glucocorticosteroids are the first-line therapy for controlling airway inflammation in asthma.
They bind intracellular glucocorticoid receptors to trigger increased expression of anti …

Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic …

Introduction Corticosteroids are the most cost-effective anti-inflammatory drugs available for
the treatment of asthma. Despite their effectiveness, several asthmatic patients have …

Asthma is a chronic disease of the airways characterized by reversible airflow obstruction,
airway hyperresponsiveness, and airway inflammation. As understanding of the …

Glucocorticoids are currently the most effective anti-inflammatory therapy for asthma.
However, a small subset of asthma sufferers do not respond to clinically relevant doses of …

Glucocorticoid insensitivity presents a profound management problem in patients with
asthma because conventional therapies are not effective. Glucocorticoids, acting through the …

Glucocorticoids are the mainstay of asthma management and effectively treat acute
exacerbations of asthma. However, a small subset of asthmatics, usually with severe …

The disproportionate cost of treating asthmatic patients who do not respond to conventional
anti-inflammatory therapies makes delineation of the mechanism for glucocorticoid …