Targeting the microenvironment of vulnerable atherosclerotic plaques: an emerging diagnosis and therapy strategy for atherosclerosis

S Zhang, Y Liu, Y Cao, S Zhang, J Sun… - Advanced …, 2022 - Wiley Online Library
Atherosclerosis is considered one of the primary causes of cardiovascular diseases (CVDs).
Unpredictable rupture of the vulnerable atherosclerotic plaques triggers adverse …

[HTML][HTML] Vulnerable plaque, characteristics, detection, and potential therapies

A Hafiane - Journal of cardiovascular development and disease, 2019 - mdpi.com
Plaque development and rupture are hallmarks of atherosclerotic vascular disease. Despite
current therapeutic developments, there is an unmet necessity in the prevention of …

[HTML][HTML] Current advances in the diagnostic imaging of atherosclerosis: insights into the pathophysiology of vulnerable plaque

NV Mushenkova, VI Summerhill, D Zhang… - International journal of …, 2020 - mdpi.com
Atherosclerosis is a lipoprotein-driven inflammatory disorder leading to a plaque formation
at specific sites of the arterial tree. After decades of slow progression, atherosclerotic plaque …

Vulnerable plaque imaging: updates on new pathobiological mechanisms

K Toutouzas, G Benetos, A Karanasos… - European heart …, 2015 - academic.oup.com
Early identification of vulnerable, rupture-prone atherosclerotic plaques with the optimal goal
of cardiovascular event prevention is a field of vigorous research. Despite the advances in …

Recent advances in managing atherosclerosis via nanomedicine

CKW Chan, L Zhang, CK Cheng, H Yang, Y Huang… - Small, 2018 - Wiley Online Library
Atherosclerosis, driven by chronic inflammation of the arteries and lipid accumulation on the
blood vessel wall, underpins many cardiovascular diseases with high mortality rates …

Advances in the understanding of plaque composition and treatment options: year in review

MI Tomey, J Narula, JC Kovacic - Journal of the American College of …, 2014 - jacc.org
Atherosclerosis research has classically followed 2 intertwining lines of investigation
concerning atherosclerosis as a local process (the “high-risk plaque”) and as a systemic …

[HTML][HTML] Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment

X Zhang, F Centurion, A Misra, S Patel, Z Gu - Advanced drug delivery …, 2023 - Elsevier
Atherosclerosis, a chronic cardiovascular disease caused by plaque development in
arteries, remains a leading cause of morbidity and mortality. Atherosclerotic plaques are …

[HTML][HTML] Detection of vulnerable coronary plaques using invasive and non-invasive imaging modalities

A van Veelen, NMR van der Sangen, R Delewi… - Journal of clinical …, 2022 - mdpi.com
Acute coronary syndrome (ACS) mostly arises from so-called vulnerable coronary plaques,
particularly prone for rupture. Vulnerable plaques comprise a specific type of plaque, called …

Intravascular detection of the vulnerable plaque

WM Suh, AH Seto, RJP Margey… - Circulation …, 2011 - Am Heart Assoc
Coronary heart disease (CHD) remains the leading cause of death in the United States, and
an estimated 1.4 million Americans have a heart attack each year. Over the past 2 decades …

Atherosclerotic plaque rupture: identifying the straw that breaks the camel's back

YC Chen, AL Huang, TS Kyaw, A Bobik… - … , and vascular biology, 2016 - Am Heart Assoc
e64 Arterioscler Thromb Vasc Biol August 2016 plaques. Magnetic resonance imaging
(MRI) and positron emission tomography, and in particular the combination of both …