It is well‏‏ established that macrophages are key regulators of wound healing, displaying
impressive plasticity and an evolving phenotype, from an aggressive pro-inflammatory or" …

Non-healing wounds in Type 2 Diabetes (T2D) patients represent the most common cause
of amputation in the US, with an associated 5-year mortality of nearly 50%. Our lab has …

The healing of cutaneous wounds is dependent on the progression through distinct, yet
overlapping phases of wound healing, including hemostasis, inflammation, proliferation, and …

Macrophages are key immune cells that respond to infections, and modulate
pathophysiological conditions such as wound healing. By possessing phagocytic activities …

Macrophage differentiation and polarization are essential players in the success of the
wound-healing process. Acute simple wounds progress from inflammation to proliferation …

Macrophages play a prominent role in wound healing. In the early stages, they promote
inflammation and remove pathogens, wound debris, and cells that have apoptosed. Later in …

Monocytes (Mo) and macrophages (Mϕ) play important roles in normal skin wound healing,
and dysregulation of wound Mo/Mϕ leads to impaired wound healing in diabetes. Although …

Macrophages regulate cutaneous wound healing by immune surveillance, tissue repair and
remodelling. The depletion of dermal macrophages during the early and middle stages of …

The monocyte lineage is essential to normal wound healing. Macrophage inhibition or
knockout in mice results in impaired wound healing through reduced neovascularization …

Purpose The failure in timely healing of wounds is a central feature in chronic wounds that
leads to physiological, psychological and economic burdens. Macrophages have been …