High Antibodies to VAR2CSA in Response to Malaria Infection Are Associated With Improved Birthweight in a Longitudinal Study of Pregnant Women

JYA Doritchamou - Immunity to Parasitic Infections in Pregnancy, 2022 - books.google.com
Methods: Levels of IgG against VAR2CSA domains (DBL3; DBL5) and a VAR2CSA-
expressing placental-binding P. falciparum isolate (PfCS2-IE) were measured in 301 women …

High antibodies to VAR2CSA in response to malaria infection are associated with improved birthweight in a longitudinal study of pregnant women

ARD McLean, DH Opi, DI Stanisic, JC Cutts… - Frontiers in …, 2021 - frontiersin.org
Introduction Pregnant women have an increased risk of P. falciparum infection, which is
associated with low birth weight and preterm delivery. VAR2CSA, a variant surface antigen …

Antibody levels to recombinant VAR2CSA domains vary with Plasmodium falciparum parasitaemia, gestational age, and gravidity, but do not predict pregnancy …

M Fried, JD Kurtis, B Swihart, R Morrison, S Pond-Tor… - Malaria Journal, 2018 - Springer
Background Maternal malaria is a tropical scourge associated with poor pregnancy
outcomes. Women become resistant to Plasmodium falciparum pregnancy malaria as they …

The Quantity, Quality and Two Major Effector Functions of Antibodies to VAR2CSA and their Association with Pregnancy Outcomes in a Low Malaria Transmission …

YM Lloyd, N Bobbili, A Salanti, P Gwanmesia… - Medical Research …, 2023 - esmed.org
Background: Women produce antibodies to VAR2CSA when infected with Plasmodium
falciparum during pregnancy that reduce disease severity in the current and subsequent …

The Development, Fine Specificity, and Importance of High-Avidity Antibodies to VAR2CSA in Pregnant Cameroonian Women Living in Yaounde, an Urban City

AJF Luty - Immunity to Parasitic Infections in Pregnancy, 2022 - books.google.com
Plasmodium falciparum infections during pregnancy may be harmful to both the mother and
the developing fetus. Malariainfected erythrocytes (IE) sequester in the intervillous space …

Plasmodium falciparum VAR2CSA-Specific IgG Subclass Responses Reflect Protection Against Low Birth Weight and Pregnancy-Associated Malaria

B Tornyigah, T d'Almeida, G Escriou, F Viwami… - Frontiers in …, 2021 - frontiersin.org
Sequestration of Plasmodium falciparum-infected erythrocytes expressing the VAR2CSA
antigen in the placenta results in poor pregnancy outcomes, including low birth weight and …

Improved Pregnancy Outcomes in Women Exposed to Malaria With High Antibody Levels Against Plasmodium falciparum

A Mayor, U Kumar, A Bardají, P Gupta… - The Journal of …, 2013 - academic.oup.com
Abstract Background. Antibodies against VAR2CSA, the Plasmodium falciparum variant
surface antigen that binds placental chondroitin sulfate A, have been suggested to mediate …

Differential evolution of anti-VAR2CSA- IgG3 in primigravidae and multigravidae pregnant women infected by Plasmodium falciparum

J Guitard, G Cottrell, NM Magnouha, A Salanti, T Li… - Malaria Journal, 2008 - Springer
Background Pregnant women develop protective anti-VSA IgG1 and IgG3 when infected by
Plasmodium falciparum. The major target of IgG from serum of infected pregnant women is …

VAR2CSA-Specific IgG Subclass Responses Reflect Protection Against Low Birth Weight and Pregnancy-Associated Malaria

MS Duthiem, S Joshi, P Jagannathan… - Immunity to Parasitic …, 2022 - books.google.com
Sequestration of Plasmodium falciparum-infected erythrocytes expressing the VAR2CSA
antigen in the placenta results in poor pregnancy outcomes, including low birth weight and …

Infections with Plasmodium falciparum during pregnancy affect VAR2CSA DBL-5 domain-specific T cell cytokine responses

K Gbédandé, G Cottrell, B Vianou, S Ibitokou… - Malaria Journal, 2016 - Springer
Background Current knowledge of human immunological responses to pregnancy-
associated malaria-specific Plasmodium falciparum protein VAR2CSA concerns almost …