Recent advances and limitations of mTOR inhibitors in the treatment of cancer
Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR)
signaling pathway is important in a variety of biological activities, including cellular …
signaling pathway is important in a variety of biological activities, including cellular …
mTOR pathway and mTOR inhibitors as agents for cancer therapy
P Baldo, S Cecco, E Giacomin… - Current cancer drug …, 2008 - ingentaconnect.com
Research into mTOR, mammalian Target Of Rapamycin as an important drug target
continues to be extremely interesting, both in terms of the increased molecular knowledge …
continues to be extremely interesting, both in terms of the increased molecular knowledge …
Targeting mTOR pathways in human malignancies
A Fasolo, C Sessa - Current pharmaceutical design, 2012 - ingentaconnect.com
Background: The mammalian target of rapamycin (mTOR) is a protein kinase involved in the
phosphatidylinositol 3-Kinase (PI3K)/AKT signalling pathway with a central role in the …
phosphatidylinositol 3-Kinase (PI3K)/AKT signalling pathway with a central role in the …
Therapeutic targets: MTOR and related pathways
JE Dancey - Cancer biology & therapy, 2006 - Taylor & Francis
The mammalian target of rapamycin (mTOR), a protein kinase of the phosphatidylinositol 3-
kinase (PI3K)/Akt signaling pathway, has a central role in controlling malignant cellular …
kinase (PI3K)/Akt signaling pathway, has a central role in controlling malignant cellular …
Pushing the envelope in the mTOR pathway: the second generation of inhibitors
E Vilar, J Perez-Garcia, J Tabernero - Molecular cancer therapeutics, 2011 - AACR
Abstract The phosphatidylinositol-3-kinase (PI3K)/mTOR pathway has been a major focus of
attention for cancer researchers in the past decade. A preliminary and incomplete …
attention for cancer researchers in the past decade. A preliminary and incomplete …
Targeting mTOR for cancer treatment
B Rubio-Viqueira, M Hidalgo - New trends in cancer for the 21st century, 2006 - Springer
The mammalian target of rapamycin (mTOR) is involved in the control of cellular growth and
proliferation. Abnormal activation of signaling pathways both proximal and distal to this …
proliferation. Abnormal activation of signaling pathways both proximal and distal to this …
Recent clinical trials of mTOR-targeted cancer therapies
AS Arachchige Don… - Reviews on recent …, 2011 - ingentaconnect.com
The mammalian target of rapamycin (mTOR) is a central component within a complex
intracellular signaling network that regulates various processes including cell growth …
intracellular signaling network that regulates various processes including cell growth …
mTOR signaling and drug development in cancer
J Dancey - Nature reviews Clinical oncology, 2010 - nature.com
Mammalian target of rapamycin (mTOR) is a protein kinase of the PI3K/Akt signaling
pathway. Activation of mTOR in response to growth, nutrient and energy signals leads to an …
pathway. Activation of mTOR in response to growth, nutrient and energy signals leads to an …
Drug discovery targeting the mTOR pathway
AM Martelli, F Buontempo, JA McCubrey - Clinical Science, 2018 - portlandpress.com
Mechanistic target of rapamycin (mTOR) is the kinase subunit of two structurally and
functionally distinct large multiprotein complexes, referred to as mTOR complex 1 (mTORC1) …
functionally distinct large multiprotein complexes, referred to as mTOR complex 1 (mTORC1) …
mTOR inhibitors in cancer therapy
YY Zaytseva, JD Valentino, P Gulhati, BM Evers - Cancer letters, 2012 - Elsevier
The mammalian target of rapamycin (mTOR) plays a key role in regulation of cellular
metabolism, growth, and proliferation. The frequent hyperactivation of mTOR signaling …
metabolism, growth, and proliferation. The frequent hyperactivation of mTOR signaling …