[HTML][HTML] The Cystine/Glutamate Antiporter, System xc–, Contributes to Cortical Infarction After Moderate but Not Severe Focal Cerebral Ischemia in Mice
Y He, SJ Hewett - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Understanding the mechanisms underlying ischemic brain injury is of importance to the goal
of devising novel therapeutics for protection and/or recovery. Previous work in our laboratory …
of devising novel therapeutics for protection and/or recovery. Previous work in our laboratory …
Regulation of System xc−Activity and Expression in Astrocytes by Interleukin‐1β: Implications for Hypoxic Neuronal Injury
We recently demonstrated that interleukin‐1β (IL‐1β) increases system
xc−(cystine/glutamate antiporter) activity in mixed cortical cell cultures, resulting in an …
xc−(cystine/glutamate antiporter) activity in mixed cortical cell cultures, resulting in an …
Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc as a neuroprotective drug target
P Albrecht, J Lewerenz, S Dittmer… - CNS & Neurological …, 2010 - ingentaconnect.com
The glutamate/cystine antiporter system xc¯ transports cystine into cells in exchange for the
important neurotransmitter glutamate at a ratio of 1: 1. It is composed of a specific light chain …
important neurotransmitter glutamate at a ratio of 1: 1. It is composed of a specific light chain …
Dopaminergic neurons of system xc-deficient mice are protected against 6-OHDA induced toxicity
A Massie, A Schallier, SW Kim… - Annual meeting of …, 2010 - researchportal.vub.be
Abstract System xc-or the cystine/glutamate antiporter exchanges extracellular cystine for
intracellular glutamate. Intracellularly cystine is reduced to cysteine, the rate-limiting …
intracellular glutamate. Intracellularly cystine is reduced to cysteine, the rate-limiting …
Main path and byways: non‐vesicular glutamate release by system xc− as an important modifier of glutamatergic neurotransmission
A Massie, S Boillee, S Hewett… - Journal of …, 2015 - Wiley Online Library
Abstract System xc− is a cystine/glutamate antiporter that exchanges extracellular cystine for
intracellular glutamate. Cystine is intracellularly reduced to cysteine, a building block of …
intracellular glutamate. Cystine is intracellularly reduced to cysteine, a building block of …
System xc‐ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS
RJ Bridges, NR Natale, SA Patel - British journal of …, 2012 - Wiley Online Library
System xc‐is an amino acid antiporter that typically mediates the exchange of extracellular l‐
cystine and intracellular l‐glutamate across the cellular plasma membrane. Studied in a …
cystine and intracellular l‐glutamate across the cellular plasma membrane. Studied in a …
Tonic extracellular glutamate and ischaemia: glutamate antiporter system xc− regulates anoxic depolarization in hippocampus
BS Heit, A Chu, A Sane, DE Featherstone… - The Journal of …, 2023 - Wiley Online Library
In stroke, the sudden deprivation of oxygen to neurons triggers a profuse release of
glutamate that induces anoxic depolarization (AD) and leads to rapid cell death. Importantly …
glutamate that induces anoxic depolarization (AD) and leads to rapid cell death. Importantly …
Regulation of xCT expression and system function in neuronal cells
J Lewerenz, P Maher, A Methner - Amino acids, 2012 - Springer
The glutamate/cystine antiporter system x_ c^-transports cystine into cells in exchange for
glutamate at a ratio of 1: 1. It is composed of a specific light chain, xCT, and a heavy chain …
glutamate at a ratio of 1: 1. It is composed of a specific light chain, xCT, and a heavy chain …
System xc− activity and astrocytes are necessary for interleukin-1β-mediated hypoxic neuronal injury
B Fogal, J Li, D Lobner, LD McCullough… - Journal of …, 2007 - Soc Neuroscience
The purpose of this study was to elucidate the cellular/biochemical pathway (s) by which
interleukin-1β (IL-1β) contributes to the pathogenesis of hypoxic–ischemic brain damage. In …
interleukin-1β (IL-1β) contributes to the pathogenesis of hypoxic–ischemic brain damage. In …
Cystine/glutamate antiporter blockage induces myelin degeneration
The cystine/glutamate antiporter is a membrane transport system responsible for the uptake
of extracellular cystine and release of intracellular glutamate. It is the major source of cystine …
of extracellular cystine and release of intracellular glutamate. It is the major source of cystine …