Two drug-drug salt forms of multimodal antidepressant drug vortioxetine (VOT), with non-
sterodial anti-inflammatory drugs (NSAIDs), mefenamic acid (MFA) and tolfenamic acid …

Abstract Three 1: 1 salts containing vortioxetine (VOT), an orally antidepressant drug, and 3
aryl monoacids have been designed and successfully prepared by liquid-assisted grinding …

Vortioxetine (VOT) is a serotonin (5-HT) receptor antagonist used for the treatment of major
depressive disorder, but its poor solubility limits its absorption in vivo. This study aimed to …

Two vortioxetine (VOT) salts with hydrochloride (VOT-HCl and VOT-0.5 HCl) were prepared
and structurally characterized. VOT-HCl features 1-dimensional P/M helical chains through …

In the present work, novel salts of the multimodal antidepressant drug vortioxetine (VT) were
crystallized with pharmaceutically acceptable acids, aiming to improve the solubility of VT …

The purpose of this study was to improve the solubility of vortioxetine by crystal engineering
principles. In this paper, three C2-C4 straight-chain dicarboxylic acid salt hydrates of …

Vortioxetine (VTX) is a novel multimodal antidepressant drug that affects the serotoninergic
and noradrenergic systems. In this work, the forced degradation of VTX was studied …

The current study reports the development and validation of a stability-indicating reversed
phase HPLC method for the separation and identification of potential impurities in …

Drug solubility plays a significant role in the development of drug formulation. The objectives
of this work are to improve the solubility and dissolution rate of vortioxetine (VT) by preparing …

Vortioxetine is a multimodal antidepressant that has been recently utilized globally.
Vortioxetine hemi‐hydrochloride is a novel salt that was previously reported in our research …