Trophoblast organoids derived from placental villi provide a 3D model system of human
placental development, but access to first-trimester tissues is limited. Here, we report that …

Appropriate human trophoblast lineage specification and differentiation is crucial for the
establishment of normal placentation and maintenance of pregnancy. However, due to the …

Defective placentation is the underlying cause of various pregnancy complications, such as
severe intrauterine growth restriction and preeclampsia. However, studies on human …

The human placenta is essential for successful reproduction. There is great variation in the
anatomy and development of the placenta in different species, meaning that animal models …

Human trophoblast stem cells (hTSCs) derived from blastocysts and first-trimester
cytotrophoblasts offer an unprecedented opportunity to study the placenta. However, access …

In eutherians, the placenta acts as a barrier and conduit at the maternal-fetal interface.
Syncytiotrophoblasts, the multinucleated cells that cover the placental villous tree surfaces of …

Trophoblasts are extraembryonic cells that are essential for maintaining pregnancy. Human
trophoblasts arise from the morula as trophectoderm (TE), which, after implantation …

The use of in vitro tools to study trophoblast differentiation and function is essential to
improve understanding of normal and abnormal placental development. The relative …

The maintenance of gestational well-being requires the proper development of both the
embryo and the placenta. Placental trophoblast cells are the major building blocks of the …

Direct in vivo investigation of human placenta trophoblast's susceptibility to SARS-CoV-2 is
challenging. Here we report that human trophoblast stem cells (hTSCs) and their derivatives …