Long non-coding RNAs: novel regulators of cellular physiology and function

JA Oo, RP Brandes, MS Leisegang - Pflügers Archiv-European Journal of …, 2022 - Springer
Long non-coding RNAs were once considered as “junk” RNA produced by aberrant DNA
transcription. They are now understood to play central roles in diverse cellular processes …

Roles for long non-coding RNAs in physiology and disease

MT Melissari, P Grote - Pflügers Archiv-European Journal of Physiology, 2016 - Springer
While the vast majority of the genome is transcribed into RNA, only a small fraction of these
transcripts have protein-coding potential. A large fraction of the transcribed RNA belongs to …

[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions

L Statello, CJ Guo, LL Chen, M Huarte - Nature reviews Molecular cell …, 2021 - nature.com
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …

Long noncoding RNA: genomics and relevance to physiology

Y Kong, Z Lu, P Liu, Y Liu, F Wang… - Comprehensive …, 2011 - Wiley Online Library
The mammalian cell expresses thousands of long noncoding RNAs (lncRNAs) that are
longer than 200 nucleotides but do not encode any protein. lncRNAs can change the …

Molecular functions and biological roles of long non‐coding RNAs in human physiology and disease

F Kopp - The journal of gene medicine, 2019 - Wiley Online Library
The human genome has been demonstrated to be pervasively transcribed, with a large
fraction of the transcriptome representing non‐protein‐coding RNA species. A relatively …

Besides pathology: long non-coding RNA in cell and tissue homeostasis

A Salviano-Silva, SC Lobo-Alves, RC Almeida… - Non-coding RNA, 2018 - mdpi.com
A significant proportion of mammalian genomes corresponds to genes that transcribe long
non-coding RNAs (lncRNAs). Throughout the last decade, the number of studies concerning …

Long noncoding RNAs: lincs between human health and disease

ZH Kwok, Y Tay - Biochemical Society Transactions, 2017 - portlandpress.com
Long noncoding RNAs (lncRNAs) represent one of the largest classes of transcripts and are
highly diverse in terms of characteristics and functions. Advances in high-throughput …

Mechanisms of long noncoding RNA function in development and disease

SU Schmitz, P Grote, BG Herrmann - Cellular and molecular life sciences, 2016 - Springer
Since decades it has been known that non-protein-coding RNAs have important cellular
functions. Deep sequencing recently facilitated the discovery of thousands of novel …

Long noncoding RNA: its physiological and pathological roles

B Yan, Z Wang - DNA and Cell Biology, 2012 - liebertpub.com
Long noncoding RNAs (lncRNAs) are transcribed RNA molecules> 200 nucleotides in
length. They comprise a diverse class of transcripts that structurally resemble mRNAs, but do …

Physiological roles of long noncoding RNAs: insight from knockout mice

L Li, HY Chang - Trends in cell biology, 2014 - cell.com
Long noncoding RNAs (lncRNAs) are a pervasive and recently recognized class of genes.
lncRNAs have been proposed to modulate gene expression and nuclear architecture, but …