Background: Myocardial ischemia-reperfusion (I/R) injury causes cardiac dysfunction to
myocardial cell loss and fibrosis. Prevention of cell death is important to protect cardiac …

Lipid peroxidation (LPO) is one of the most damaging processes in chemodynamic therapy
(CDT). Although it is well known that polyunsaturated fatty acids (PUFAs) are much more …

As a rising generation of nanozymes, single atom enzymes show significant promise for
cancer therapy, due to their maximum atom utilization efficiency and well-defined electronic …

Understanding the intricate molecular machinery that governs ferroptosis and leveraging
this accumulating knowledge could facilitate disease prevention, diagnosis, treatment, and …

The aryl-hydrocarbon receptor (AHR) is a ligand-activated transcription factor that buoys
intestinal immune responses. AHR induces its own negative regulator, the AHR repressor …

Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

Here, we identified vitamin K epoxide reductase complex subunit 1 like 1 (VKORC1L1) as a
potent ferroptosis repressor. VKORC1L1 protects cells from ferroptosis by generating the …

Malignant tumors exhibit heterogeneous metabolic reprogramming, hindering the
identification of translatable vulnerabilities for metabolism-targeted therapy. How molecular …

Ferroptosis is a recently discovered essential type of cell death that is mainly characterized
by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a …

The ongoing metabolic and microbicidal pathways that support and protect cellular life
generate potentially damaging reactive oxygen species (ROS). To counteract damage, cells …