Gastrulation is considered the sine qua non of embryogenesis, establishing a
multidimensional structure and the spatial coordinates upon which all later developmental …

Cancer-specific metabolic activities play a crucial role in the pathogenesis of human
malignancies. To investigate human acute leukemia–specific metabolic properties, we …

Chaperone‐mediated autophagy (CMA) is a lysosomal degradation pathway that eliminates
substrate proteins through heat‐shock cognate protein 70 recognition and lysosome …

Breast cancer (BC) is the most frequently diagnosed cancer and one of the major causes of
cancer death. Despite enormous progress in its management, both from the therapeutic and …

Maternal folate deficiency increases the risk of neural tube defects (NTDs), but the
mechanism remains unclear. Here, we established a mouse model of NTDs via low folate …

Maternal metabolic disorders may cause lipotoxic effects on the developing oocyte.
Understanding the timing at which this might disrupt embryo epigenetic programming and …

Abstract Background/Aims: Currently, it is proven that the cellular metabolism of nitric oxide
is necessary to maintain optimal health and adaptation of the organism to the impact of …

White adipocytes play a key role in the regulation of fat mass amount and energy balance.
An appropriate level of white adipocyte differentiation is important for maintaining metabolic …

An instructive role for metabolism in embryonic patterning is emerging, although a role for
mitochondria is poorly defined. We demonstrate that mitochondrial oxidative metabolism …

Aim The osseointegration of dental implants is impaired in patients with osteoporosis,
leading to significantly higher failure rates. This study set out to investigate the potential …