MRAβ: A multimodal MRI‐derived amyloid‐β biomarker for Alzheimer's disease
Y Zhang, X Li, Y Ji, H Ding, X Suo, X He… - Human Brain …, 2023 - Wiley Online Library
Abstract Florbetapir 18F (AV45), a highly sensitive and specific positron emission
tomographic (PET) molecular biomarker binding to the amyloid‐β of Alzheimer's disease …
tomographic (PET) molecular biomarker binding to the amyloid‐β of Alzheimer's disease …
Fast and accurate amyloid brain PET quantification without MRI using deep neural networks
SK Kang, D Kim, SA Shin, YK Kim… - Journal of Nuclear …, 2023 - Soc Nuclear Med
This paper proposes a novel method for automatic quantification of amyloid PET using deep
learning–based spatial normalization (SN) of PET images, which does not require MRI or CT …
learning–based spatial normalization (SN) of PET images, which does not require MRI or CT …
Preclinical evaluation of novel PET probes for dementia
R Cools, K Kerkhofs, RCF Leitao, G Bormans - Seminars in Nuclear …, 2023 - Elsevier
The development of novel PET imaging agents that selectively bind specific dementia-
related targets can contribute significantly to accurate, differential and early diagnosis of …
related targets can contribute significantly to accurate, differential and early diagnosis of …
Imaging methods applicable in the diagnostics of Alzheimer's disease, considering the involvement of insulin resistance
P Hnilicova, E Kantorova, S Sutovsky, M Grofik… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is an incurable neurodegenerative disease and the most
frequently diagnosed type of dementia, characterized by (1) perturbed cerebral perfusion …
frequently diagnosed type of dementia, characterized by (1) perturbed cerebral perfusion …
Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study
Background: Estimates of 'brain-predicted age'quantify apparent brain age compared to
normative trajectories of neuroimaging features. The brain age gap (BAG) between …
normative trajectories of neuroimaging features. The brain age gap (BAG) between …
Longitudinal head-to-head comparison of 11C-PiB and 18F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly …
Abstract Purpose Pittsburgh Compound-B (11C-PiB) and 18F-florbetapir are amyloid-β (Aβ)
positron emission tomography (PET) radiotracers that have been used as endpoints in …
positron emission tomography (PET) radiotracers that have been used as endpoints in …
Microglial activation, tau and amyloid deposition in TREM2 p. R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study …
Background Microglia are increasingly understood to play an important role in the
pathogenesis of Alzheimer's disease. The rs75932628 (p. R47H) TREM2 variant is a well …
pathogenesis of Alzheimer's disease. The rs75932628 (p. R47H) TREM2 variant is a well …
Operationalizing the centiloid scale for [18F]florbetapir PET studies on PET/MRI
INTRODUCTION The Centiloid scale aims to harmonize amyloid beta (Aβ) positron
emission tomography (PET) measures across different analysis methods. As Centiloids were …
emission tomography (PET) measures across different analysis methods. As Centiloids were …
Head-to-head comparison of relative cerebral blood flow derived from dynamic [18F]florbetapir and [18F]flortaucipir PET in subjects with subjective cognitive decline
H Tuncel, D Visser, T Timmers, EE Wolters… - EJNMMI research, 2023 - Springer
Background Dynamic PET imaging studies provide accurate estimates of specific binding,
but also measure the relative tracer delivery (R1), which is a proxy for relative cerebral blood …
but also measure the relative tracer delivery (R1), which is a proxy for relative cerebral blood …
A new accuracy metric under three classes when subclasses are involved and its confidence interval estimation
“Compound multi‐class classification” refers to the setting where three or more main classes
are involved and at least one of the main classes have multiple subclasses. A common …
are involved and at least one of the main classes have multiple subclasses. A common …