BACKGROUND Trauma hemorrhage remains the most common cause of preventable
mortality in trauma. To guide clinical practice, RCTs provide high-quality evidence to inform …

Abstract Introduction Hyperfibrinolysis diagnosed on Rotational Thromboelastography
(ROTEM) is associated with increased transfusion requirements and mortality in trauma. The …

Even with extensive transfusion support, trauma-induced bleeding often leads to death.
Early intervention may improve outcomes, yet which blood products, factor concentrates, or …

During the past decade, more and more large-scale pragmatic clinical trials have been
carried out in orthopedic trauma surgery. This trend is fueled by the common belief that the …

Interplay between platelets, coagulation/fibrinolytic factors, and endothelial cells (ECs) is
necessary for effective hemostatic plug formation. This study describes a novel four …

Background Remote damage control resuscitation (RDCR) aims to apply the principles of
damage control resuscitation to prehospital and austere care, emphasizing early control of …

Methods A secondary analysis was performed using harmonized data from two large,
double-blinded, randomized prehospital TXA trials. Outcomes, including 28-day mortality …

Tranexamic Acid (TXA) has been used in medical and surgical practice to reduce
haemorrhage. The aim of this review was to evaluate the effect of TXA use on intraoperative …

Trauma is the leading nonobstetric cause of maternal death and affects 1 in 12 pregnancies
in the United States. Adhering to the fundamentals of the advanced trauma life support …

Background Warzone humanitarian medical aid missions are infrequent and applying
lessons from these missions is vital to ensuring preparedness for future crises. Between …