Objectives Pre-trial acceptability studies may boost recruitment, especially in trials
comparing distinctly different interventions. We evaluated the impact of an acceptability …

Background: Inability to retain participants in a clinical trial poses a threat to clinical research
as it can lead to a number of issues ultimately affecting generalisability, validity and …

We aimed to explore the clinical relevance of a multicentre, pragmatic randomised trial of
antipsychotic reduction in people diagnosed with schizophrenia or psychosis The sample …

Background: Patient recruitment is the universal rate-limiting factor for randomized
controlled trials (RCTs) in all medical specialties. This study examined the opinions on …

Aims and MethodTo estimate the proportion of attrition at which results of drug trials for
people with schizophrenia lose enough credibility to become mistrusted by relevant groups …

Importance Most evidence about efficacy and safety of antipsychotics in schizophrenia
spectrum disorders relies on randomized clinical trials (RCTs). However, owing to their strict …

29 bias), which led to its authors being unable to draw any clear conclusions (19), although
Fleischhacker and Goodwin seem now more prepared to do so. Space precludes a …

Background: There is a great need for effective treatments for mental health problems.
Randomised controlled trials are the gold standard for evaluating treatments, however …

Background Treatment of those at clinical highrisk (CHR) for developing psychosis may
lead to preventive strategies. However, attrition in trials may hamper efforts to detect effective …

Recruitment and retention of research participants is often the most labor-intensive and
difficult component of clinical trials. Poor recruitment and retention frequently pose as a …