Beschreibungen: Die Sepsis stellt weiterhin ein relevantes Krankheitsbild mit hoher
Sterblichkeit und steigenden Fallzahlen dar. Neben einer Beeinträchtigung auf Ebene der …

Recent studies observed, despite an anti-hyperlipidaemic effect, a positive impact of fibrates
on septic conditions. This study evaluates the effects of gemfibrozil on microcirculatory …

Background Tissue ATP depletion and oxidative stress have been associated with the
severe outcomes of septic shock. One of the compensatory mechanisms to alleviate the …

Background Evidence suggests that early adaptive responses of hepatic mitochondria occur
in experimentally induced sepsis. Little is known about both colonic mitochondrial function …

The link between liver dysfunction and decreased mitochondrial oxidative phosphorylation
in sepsis has been clearly established in experimental models. Energy transduction is …

During sepsis, liver dysfunction is common, and failure of mitochondria to effectively couple
oxygen consumption with energy production has been described. In addition to sepsis …

Through their pleiotropic actions, statins, fibrates, thiazolidinediones and resveratrol can
target multiple mechanisms involved in sepsis. Their actions on mitochondrial function are of …

Beschreibungen: Funktionstüchtige Mitochondrien sind für die Integrität des Organismus
unabdingbar, da sie eine zentrale Rolle in der Energiebereitstellung für die Zelle durch die …

Organ injury in sepsis is initially characterized by dysfunction without cell death and
structural damage, and thus with the ability to recover organ function. Adaptive metabolic …

Background The relevance of mitochondrial dysfunction as to pathogenesis of multiple
organ dysfunction and failure in sepsis is controversial. This focused review evaluates the …