NAD+ metabolism-based immunoregulation and therapeutic potential

J Fang, W Chen, P Hou, Z Liu, M Zuo, S Liu, C Feng… - Cell & Bioscience, 2023 - Springer
Nicotinamide adenine dinucleotide (NAD+) is a critical metabolite that acts as a cofactor in
energy metabolism, and serves as a cosubstrate for non-redox NAD+-dependent enzymes …

Host NAD+ metabolism and infections: therapeutic implications

A Singhal, CY Cheng - International Immunology, 2019 - academic.oup.com
Nicotinamide adenine dinucleotide (NAD+) is both a crucial coenzyme and a cosubstrate for
various metabolic reactions in all living cells. Maintenance of NAD+ levels is essential for …

Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing

MN Navarro, MM Gómez de Las Heras… - British journal of …, 2022 - Wiley Online Library
Metabolism is dynamically regulated to accompany immune cell function, and altered
immunometabolism can result in impaired immune responses. Concomitantly, the …

Exploring NAD+ metabolism in host–pathogen interactions

I Mesquita, P Varela, A Belinha, J Gaifem… - Cellular and molecular …, 2016 - Springer
Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+
intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway …

NAD+ in COVID-19 and viral infections

M Zheng, MB Schultz, DA Sinclair - Trends in Immunology, 2022 - cell.com
NAD+, as an emerging regulator of immune responses during viral infections, may be a
promising therapeutic target for coronavirus disease 2019 (COVID-19). In this Opinion, we …

[HTML][HTML] Dihydronicotinamide riboside is a potent NAD+ precursor promoting a pro-inflammatory phenotype in macrophages

C Chini, TR Peclat, LS Gomez, JD Zeidler… - Frontiers in …, 2022 - frontiersin.org
Nicotinamide adenine dinucleotide (NAD) metabolism plays an important role in the
regulation of immune function. However, a complete picture of how NAD, its metabolites …

NAD+ Metabolism, Metabolic Stress, and Infection

B Groth, P Venkatakrishnan, SJ Lin - Frontiers in Molecular …, 2021 - frontiersin.org
Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite with wide-ranging and
significant roles in the cell. Defects in NAD+ metabolism have been associated with many …

NAD+ metabolism, stemness, the immune response, and cancer

LE Navas, A Carnero - Signal transduction and targeted therapy, 2021 - nature.com
NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …

Low cellular NAD+ compromises lipopolysaccharide-induced inflammatory responses via inhibiting TLR4 signal transduction in human monocytes

K Yang, KH Lauritzen, MB Olsen, TB Dahl… - The Journal of …, 2019 - journals.aai.org
NAD+ is an essential cofactor in reduction-oxidation metabolism with impact on metabolic
and inflammatory diseases. However, data elucidating the effects of NAD+ on the …

[HTML][HTML] The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential

X Zhang, Y Zhang, A Sun, J Ge - Genes & Diseases, 2022 - Elsevier
Recently, cardiovascular diseases (CVDs) were identified as the leading cause of mortality,
imposing a heavy burden on health care systems and the social economy. Nicotinamide …