NAD+ metabolism-based immunoregulation and therapeutic potential
J Fang, W Chen, P Hou, Z Liu, M Zuo, S Liu, C Feng… - Cell & Bioscience, 2023 - Springer
Nicotinamide adenine dinucleotide (NAD+) is a critical metabolite that acts as a cofactor in
energy metabolism, and serves as a cosubstrate for non-redox NAD+-dependent enzymes …
energy metabolism, and serves as a cosubstrate for non-redox NAD+-dependent enzymes …
Host NAD+ metabolism and infections: therapeutic implications
A Singhal, CY Cheng - International Immunology, 2019 - academic.oup.com
Nicotinamide adenine dinucleotide (NAD+) is both a crucial coenzyme and a cosubstrate for
various metabolic reactions in all living cells. Maintenance of NAD+ levels is essential for …
various metabolic reactions in all living cells. Maintenance of NAD+ levels is essential for …
Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing
MN Navarro, MM Gómez de Las Heras… - British journal of …, 2022 - Wiley Online Library
Metabolism is dynamically regulated to accompany immune cell function, and altered
immunometabolism can result in impaired immune responses. Concomitantly, the …
immunometabolism can result in impaired immune responses. Concomitantly, the …
Exploring NAD+ metabolism in host–pathogen interactions
I Mesquita, P Varela, A Belinha, J Gaifem… - Cellular and molecular …, 2016 - Springer
Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+
intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway …
intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway …
NAD+ in COVID-19 and viral infections
M Zheng, MB Schultz, DA Sinclair - Trends in Immunology, 2022 - cell.com
NAD+, as an emerging regulator of immune responses during viral infections, may be a
promising therapeutic target for coronavirus disease 2019 (COVID-19). In this Opinion, we …
promising therapeutic target for coronavirus disease 2019 (COVID-19). In this Opinion, we …
[HTML][HTML] Dihydronicotinamide riboside is a potent NAD+ precursor promoting a pro-inflammatory phenotype in macrophages
Nicotinamide adenine dinucleotide (NAD) metabolism plays an important role in the
regulation of immune function. However, a complete picture of how NAD, its metabolites …
regulation of immune function. However, a complete picture of how NAD, its metabolites …
NAD+ Metabolism, Metabolic Stress, and Infection
B Groth, P Venkatakrishnan, SJ Lin - Frontiers in Molecular …, 2021 - frontiersin.org
Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite with wide-ranging and
significant roles in the cell. Defects in NAD+ metabolism have been associated with many …
significant roles in the cell. Defects in NAD+ metabolism have been associated with many …
NAD+ metabolism, stemness, the immune response, and cancer
LE Navas, A Carnero - Signal transduction and targeted therapy, 2021 - nature.com
NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …
Low cellular NAD+ compromises lipopolysaccharide-induced inflammatory responses via inhibiting TLR4 signal transduction in human monocytes
NAD+ is an essential cofactor in reduction-oxidation metabolism with impact on metabolic
and inflammatory diseases. However, data elucidating the effects of NAD+ on the …
and inflammatory diseases. However, data elucidating the effects of NAD+ on the …
[HTML][HTML] The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential
X Zhang, Y Zhang, A Sun, J Ge - Genes & Diseases, 2022 - Elsevier
Recently, cardiovascular diseases (CVDs) were identified as the leading cause of mortality,
imposing a heavy burden on health care systems and the social economy. Nicotinamide …
imposing a heavy burden on health care systems and the social economy. Nicotinamide …