Background The extraordinarily high prevalence of treatment-resistant depression (TRD),
coupled with its high economic burden to both healthcare systems and society, underscore …

Background Major depressive disorder (MDD) is a global public health concern. In
particular, treatment-resistant depression (TRD) represents a key unmet need in the …

Background Treatment resistant depression (TRD) is diagnosed when patients experiencing
a major depressive episode fail to respond to≥ 2 treatments. Along with substantial indirect …

Objective Treatment-resistant depression (TRD), a subgroup of major depressive disorder
(MDD) that does not adequately respond to treatment, has a substantial impact on the …

Aims. The aim of this systematic review of economic evaluations alongside randomised
controlled trials (RCTs) was to provide a comprehensive overview of the evidence …

Abstract Purpose of Review We review recent advances in the treatment of treatment-
resistant depression (TRD), a disorder with very limited treatment options until recently. We …

Despite the large number of depressed patients who do not respond to first-line
antidepressants, the evidence base of alternate strategies is quite thin. In this article, a …

BACKGROUND: Major depressive disorder (MDD) is a leading cause of disability, morbidity,
and mortality worldwide. The lifetime prevalence in the United States is estimated at 17 …

BACKGROUND: High levels of public spending, rising costs of treatments and scarcity of
mental health resources have intensified the need for information on the cost-effectiveness …

BACKGROUND: Knowledge regarding the relative cost-effectiveness of different
antidepressants is crucial for the planning of depression treatment. However, there have …