Abstract The three-dimensional (3D) retinal organoids (ROs) derived from human induced
pluripotent stem cells (hiPSCs), mimicking the growth and development of the human retina …

Retinal degenerative diseases are a leading cause of blindness worldwide with debilitating
life-long consequences for the affected individuals. Cell therapy is considered a potential …

Purpose Three-dimensional retinal organoids can be differentiated from embryonic stem
cells/induced pluripotent stem cells (ES/iPS cells) under defined medium conditions. We …

Effective derivation of three-dimensional (3D) retinal tissue from human-induced pluripotent
stem cells (hiPSCs) could provide models for drug screening and facilitate patient-specific …

Purpose The generation of three-dimensional (3D) organoids with optic cup–like structures
from pluripotent stem cells has created opportunities for investigating mammalian retinal …

Background Recently, great efforts have been made to design protocols for obtaining ocular
cells from human stem cells to model diseases or for regenerative purposes. Current …

Methods for stem cell-derived, three-dimensional retinal organoids induction have been
established and shown great potential for retinal development modeling and drug …

Human-induced pluripotent stem cells (hiPSCs) can be differentiated into well-structured
retinal organoids. In this protocol, we successfully established 3D retinae from patient …

Human induced pluripotent stem cell (hiPSC)-derived three-dimensional retinal organoids
are a new platform for studying the organoidogenesis. However, recurrent genomic …

Abstract Three-dimensional (3D) retinal organoids, in vitro tissue structures derived from self-
organizing cultures of differentiating human embryonic stem cells or induced pluripotent …