As the US military pivots from years of low-intensity counterinsurgency operations to
preparation for large-scale combat operations against a near-peer competitor, the realities of …

Transfusion of plasma early after severe injury has been associated with improved survival.
There are significant logistic factors that limit the ability to deliver plasma where needed in …

The early transfusion of plasma is important to ensure optimal survival of patients with
traumatic hemorrhage. In military and remote or austere civilian settings, it may be …

BACKGROUND Trauma is the leading cause of death among adults between the ages 18
years and 40 years and the second most expensive public health problem in the United …

Recent studies have demonstrated that early transfusion of plasma or RBCs improves
survival in patients with severe trauma and hemorrhagic shock. Time to initiate transfusion is …

In the acute resuscitation of critically ill trauma patients who have sustained blood loss, there
has been a shift toward the aggressive use of blood component therapy. 1–5 Driven by an …

Uncontrollable bleeding is recognized as the leading cause of preventable death among
trauma patients. Early transfusion of blood products, especially plasma replacing crystalloid …

Challenges to modern dried plasma development exist at multiple points along the product
develop-ment cycle and include the regulatory pathway, funding, logistics, implementation …

While early plasma transfusion for the treatment of patients with ongoing major hemorrhage
is widely accepted as part of the standard of care in the hospital setting, logistic constraints …

BACKGROUND The prehospital resuscitation of the exsanguinating patient with trauma is
time and resource dependent. Rural trauma care magnifies these factors because …