Within the mammalian intestine, various microbes utilize flagellar motility to traverse the
mucus layer and reach the epithelium, challenging the spatial segregation established by …

In the mammalian intestine, flagellar motility can provide microbes competitive advantage,
but also threatens the spatial segregation established by the host at the epithelial surface …

The intestinal mucosa interfaces with a complex, dense community of microorganisms,
including hundreds of species of resident microbiota and many transient microbes entering …

Gut mucosal barrier breakdown and inflammation have been associated with high levels of
flagellin, the principal bacterial flagellar protein. Although several gut commensals can …

The discovery and therapeutic use of antibiotics made a major contribution to the reduction
of human morbidity and mortality. However, the growing resistance to antibiotics has …

Antimicrobial peptides are major effectors of the innate immunity of multicellular organisms
including human and play a critical role in host defense, and their importance has been …

Paneth cell α-defensins are antimicrobial peptides involved in the control of the intestinal
microbiota and immunological homeostasis. In mice, they are encoded by multiple, highly …

Antimicrobial peptides are important effectors of innate immunity throughout the plant and
animal kingdoms. In the mammalian small intestine, Paneth cell α-defensins are …

The intestinal microbiota is a major factor in human health and disease. This microbial
community includes autochthonous (permanent inhabitants) and allochthonous (transient …

Shigella is a Gram-negative bacterium that causes bacillary dysentery worldwide. It invades
the intestinal epithelium to elicit intense inflammation and tissue damage, yet the underlying …