Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase
in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF) …

Background—Spontaneous Ca2+ release from the sarcoplasmic reticulum (SR) can
generate afterdepolarizations, and these have the potential to initiate arrhythmias …

Aims It is unknown how β‐adrenergic stimulation affects calcium dynamics in individual
RyR2 clusters and leads to the induction of spontaneous calcium waves. To address this, we …

Calcium sparks result from the concerted opening of a small number of Ca2+ release
channels (ryanodine receptors, RyRs) organized in clusters in the membrane of the …

Atrial fibrillation (AF) is characterized by sustained high atrial activation rates and
arrhythmogenic cellular Ca2+ signaling instability; however, it is not clear how a high atrial …

Background: Many alterations in sarcoplasmic reticulum Ca 2+ handling proteins in atrial
myocytes have been associated with atrial fibrillation (AF) in clinical patients, whereas the …

Spontaneous Ca2+-release events (SCaEs) from the sarcoplasmic reticulum play crucial
roles in the initiation of cardiac arrhythmias by promoting triggered activity. However, the …

Excitation-contraction coupling in atrial cells is mediated by calcium (Ca) signaling between
L-type Ca channels and Ryanodine receptors that occurs mainly at the cell boundary. This …

Atrial myocytes have two functionally separate Ca2+ release sites: those in peripheral
sarcoplasmic reticulum (SR) adjacent to the Ca2+ channels of surface membrane and those …

Abnormalities in cardiomyocyte Ca2+ handling contribute to impaired contractile function in
heart failure (HF). Experiments on single ryanodine receptors (RyRs) incorporated into lipid …