Alteration of the tumor microenvironment by pharmacological inhibition of EZH2 in hepatocellular carcinoma

N Qiang, J Ao, M Nakamura, T Chiba… - International …, 2023 - Elsevier
Enhancer of zeste homolog 2 (EZH2), a core component of polycomb repressive component
2 is overexpressed in a variety of cancers and recognized as a therapeutic target molecule …

The functions of EZH2 in immune cells: Principles for novel immunotherapies

FF Shao, BJ Chen, GQ Wu - Journal of Leukocyte Biology, 2021 - academic.oup.com
Enhancer of zeste homolog 2 (EZH2) is aberrantly expressed or mutated in multiple types of
cancer cells and plays an oncogenic role in tumorigenesis and development in most …

EZH2 in hepatocellular carcinoma: progression, immunity, and potential targeting therapies

B Wang, Y Liu, Z Liao, H Wu, B Zhang… - … hematology & oncology, 2023 - Springer
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death. The
accumulation of genetic and epigenetic changes is closely related to the occurrence and …

Easy or Not—The Advances of EZH2 in Regulating T Cell Development, Differentiation, and Activation in Antitumor Immunity

J Huang, J Zhang, Z Guo, C Li, Z Tan, J Wang… - Frontiers in …, 2021 - frontiersin.org
Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive
complex 2 (PRC2), which regulates downstream gene expression by trimethylation of lysine …

The correlation of EZH2 expression with the progression and prognosis of hepatocellular carcinoma

S Wu, Z Xie, L Yan, X Liu, Y Zhang, D Wang, J Dong… - BMC immunology, 2022 - Springer
Abstract Background Enhancer of Zeste homologue 2 (EZH2) is a polycomb group gene and
an epigenetic regulator that inhibits transcription, a modification associated with gene …

Clinical Significance of Upregulation of EZH1 Expression in Hepatocellular Carcinoma Tissues.

SY Chen, JD Li, ZG Huang, RQ He… - … of Gastrointestinal & …, 2024 - search.ebscohost.com
Abstract Background & Aims: The incidence and mortality of hepatocellular carcinoma
(HCC) are increasing. It is urgent to develop more effective HCC biomarkers for diagnosis …

EZH2 inhibitor GSK126 suppresses antitumor immunity by driving production of myeloid-derived suppressor cells

S Huang, Z Wang, J Zhou, J Huang, L Zhou, J Luo… - Cancer Research, 2019 - AACR
Enhancer of zeste homolog (EZH2) is a key epigenetic regulator of gene expression and is
frequently overexpressed in various cancer types, suggesting a role in oncogenesis. The …

Expression of EZH2 is associated with poor outcome in colorectal cancer

Z Chen, P Yang, W Li, F He, J Wei… - Oncology …, 2018 - spandidos-publications.com
Enhancer of zeste homolog 2 (EZH2), the critical component of polycomb group protein
family, has been demonstrated to be overexpressed in various types of human cancer …

EZH2 is a negative prognostic biomarker associated with immunosuppression in hepatocellular carcinoma

B Guo, X Tan, H Cen - PLoS One, 2020 - journals.plos.org
The enhancer of zeste homolog 2 (EZH2) plays a critical role in different components of anti-
tumor immunity. However, the specific role of EZH2 in modulating MHC Class I antigen …

Analysis on EZH2: mechanism identification of related CeRNA and its immunoassay in hepatocellular carcinoma

H Zhao, H Liu, W Kang, C Zhan, Y Man, T Qu - BMC medical genomics, 2023 - Springer
Objective To screen the possible potential signaling pathways related to enhancer of zeste
homolog 2 (EZH2) based on ceRNA mechanism, and to analyze the correlation between …