Treatment with Ligilactobacillus murinus lowers blood pressure and intestinal permeability in spontaneously hypertensive rats

M Mukohda, T Yano, T Matsui, S Nakamura… - Scientific Reports, 2023 - nature.com
One feature of hypertension is a microbial imbalance with increased intestinal permeability.
In this study, we examined whether an alteration in the microbiota affects blood pressure …

Transcriptomic signature of gut microbiome-contacting cells in colon of spontaneously hypertensive rats

T Yang, H Li, AC Oliveira, R Goel… - Physiological …, 2020 - journals.physiology.org
Fecal matter transfer from hypertensive patients and animals into normotensive animals
increases blood pressure, strengthening the evidence for gut-microbiota interactions in the …

Gut microbiota dysbiosis contributes to the development of hypertension

J Li, F Zhao, Y Wang, J Chen, J Tao, G Tian, S Wu… - Microbiome, 2017 - Springer
Background Recently, the potential role of gut microbiome in metabolic diseases has been
revealed, especially in cardiovascular diseases. Hypertension is one of the most prevalent …

Genetically determined hypertensive phenotype affects gut microbiota composition, but not vice versa

P Konopelski, M Konop, K Perlejewski… - Journal of …, 2021 - journals.lww.com
Objectives: Research suggests reciprocal crosstalk between the host and gut bacteria. This
study evaluated the interaction between gut microbiota and arterial blood pressure (BP) in …

Alterations in the gut microbiota can elicit hypertension in rats

S Adnan, JW Nelson, NJ Ajami… - Physiological …, 2017 - journals.physiology.org
Gut dysbiosis has been linked to cardiovascular diseases including hypertension. We tested
the hypothesis that hypertension could be induced in a normotensive strain of rats or …

Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure

S Kim, R Goel, A Kumar, Y Qi, G Lobaton… - Clinical …, 2018 - portlandpress.com
Recent evidence indicates a link between gut pathology and microbiome with hypertension
(HTN) in animal models. However, whether this association exists in humans is unknown …

Intestinal microbiota: A promising therapeutic target for hypertension

D Sun, H Xiang, J Yan, L He - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Hypertension has developed into an escalating serious global public health problem with
multiple and unclear pathophysiological mechanisms. Recent studies have identified …

Microbiota under pressure

A Aguilar - Nature Reviews Nephrology, 2017 - nature.com
Dysbiosis of the gut microbiota is involved in severe conditions such as chronic kidney
disease but whether the gut–microbiome link is altered in hypertension has not been …

The role and mechanism of intestinal flora in blood pressure regulation and hypertension development

J Li, X Yang, X Zhou, J Cai - Antioxidants & Redox Signaling, 2021 - liebertpub.com
Significance: Hypertension (HTN) has a complex etiology that is characterized by genetic
and environmental factors. It has become a global health burden leading to cardiovascular …

Microbiota introduced to germ-free rats restores vascular contractility and blood pressure

B Joe, CG McCarthy, JM Edwards, X Cheng… - …, 2020 - Am Heart Assoc
Commensal gut microbiota are strongly correlated with host hemodynamic homeostasis but
only broadly associated with cardiovascular health. This includes a general correspondence …