Abstract Purpose of Review The intricate interplay between inflammatory and reparative
responses in the context of heart injury is central to the pathogenesis of heart failure. Recent …

The fibrotic response has evolutionary worked in tandem with the inflammatory response to
facilitate healing following injury or tissue destruction as a result of pathogen clearance …

Despite relevant advances made in therapies for cardiovascular diseases (CVDs), they still
represent the first cause of death worldwide. Cardiac fibrosis and excessive extracellular …

Fibroblasts, which are traditionally recognized as a quiescent cell responsible for
extracellular matrix production, are more and more appreciated as an active key player of …

Cardiac remodeling and inflammation are hallmarks of cardiac failure and correlate with
outcome in patients. However, the basis for the development of both remains unclear. We …

Pathological changes resulting from myocardial infarction (MI) include extracellular matrix
alterations of the left ventricle, which can lead to cardiac stiffness and impair systolic and …

Inflammation and tissue fibrosis co-exist and are causally linked to organ dysfunction.
However, the molecular mechanisms driving immune-fibroblast crosstalk in human cardiac …

The immune and fibrotic responses have evolved to work in tandem to respond to pathogen
clearance and promote tissue repair. However, excessive immune and fibrotic responses …

The mammalian heart contains a population of resident macrophages that expands in
response to myocardial infarction and hemodynamic stress. This expansion occurs likely …

Fibroblasts are essential for building and maintaining the structural integrity of all organs.
Moreover, fibroblasts can acquire an inflammatory phenotype to accommodate immune cells …