Burn injury causes a coagulopathy that is poorly understood. After severe burns, significant
fluid losses are managed by aggressive resuscitation that can lead to hemodilution. These …

Objective Early excision and grafting of burn wounds are key for reducing prevalence of
infection and sepsis. However, it is associated with massive blood loss and patients …

Background Reducing blood loss during excisional surgery in burn patients remains a
challenge. Tranexamic acid during surgery can potentially reduce blood loss. The use of …

Introduction This study was carried out to evaluate role of intravenous tranexamic acid (TXA)
in reducing blood loss during tangential excision of burns. Methods This was a single center …

Tranexamic acid (TXA), a fibrinolytic agent, effectively inhibits plasminogen activation,
thereby reducing fibrinolysis and hemorrhage. This study focused on its application in …

Besides being directly responsible for most of the early in-hospital deaths, bleeding can also
contribute to late mortality related to multiorgan failure in trauma1. Bleeding trauma patients …

Background Early excision of burn wounds is the standard approach for burns, but it is
usually associated with the need of allogeneic blood transfusion. Our aim was to determine …

Objective: To review the efficacy and safety of a single dose of intravenous tranexamic acid
(TXA) given preoperatively. Summary Background Data: TXA is a synthetic antifibrinolytic …

Methods: PubMed and Cochrane libraries were searched for relevant RCTs published
between January 2011 and January 3, 2021. Cohen's Q Test for heterogeneous effects was …

Objective Debridement of burn wounds and skin graft harvesting is associated with
increased peri-operative bleeding. In this study we evaluated the effectiveness of tranexamic …