The tumour suppressor p53, a stress‐responsive transcription factor, plays a central role in
cellular senescence. The role of p53 in senescence‐associated stable proliferative arrest …

E-mail: JCampisi@ lbl. gov www. impactaging. com AGING, July 2010, Vol. 2. No 7 www.
impactaging. com 377 AGING, July2010, Vol. 2 No. 7 determinant, it might reduce IIS. So …

Cellular senescence and the associated secretory phenotype (SASP) promote disease in
the aged population. Targeting senescent cells by means of removal, modulation of SASP or …

Transformed cells have properties that allow them to survive and proliferate inappropriately.
These characteristics often arise as a result of mutations caused by DNA damage. p53 …

Cellular senescence, a term originally used to define the characteristics of normal human
fibroblasts that reached their replicative limit, is an important factor for ageing, age-related …

The p53 transcription factor plays a critical role in cellular responses to stress. Its activation
in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs …

Cellular senescence is an established cellular stress response that acts primarily to prevent
the proliferation of cells that experience potentially oncogenic stress. In recent years, it has …

Many normal cells respond to potentially oncogenic stimuli by undergoing cellular
senescence, a state of irreversibly arrested proliferation and altered differentiated function …

Abstract p53, a guardian of the genome, exerts its tumor suppression activity by regulating a
large number of downstream targets involved in cell cycle arrest, DNA repair, apoptosis, and …

Cellular senescence is a stress response that accompanies stable exit from the cell cycle.
Classically, senescence, particularly in human cells, involves the p53 and p16/Rb pathways …