[HTML][HTML] Cannabidiol-loaded nanocarriers and their therapeutic applications

E Assadpour, A Rezaei, SS Das, BV Krishna Rao… - Pharmaceuticals, 2023 - mdpi.com
Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa,
exhibits diverse pharmacological actions. However, the applications of CBD are restricted …

[HTML][HTML] Promising nanocarriers to enhance solubility and bioavailability of cannabidiol for a plethora of therapeutic opportunities

L Grifoni, G Vanti, R Donato, C Sacco, AR Bilia - Molecules, 2022 - mdpi.com
In recent years, the interest in cannabidiol (CBD) has increased because of the lack of
psychoactive properties. However, CBD has low solubility and bioavailability, variable …

Current trends on cannabidiol delivery systems: where are we and where are we going?

ÍMM Ramalho, DT Pereira, GBL Galvão… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction Cannabidiol (CBD), a phytocannabinoid from Cannabis sativa, has several
therapeutic properties. However, its high lipophilicity, metabolization, and instability impair …

[HTML][HTML] Current Challenges and Opportunities for Improved Cannabidiol Solubility

KR Hossain, A Alghalayini, SM Valenzuela - International Journal of …, 2023 - mdpi.com
Cannabidiol (CBD), derived from the cannabis plant, has gained significant attention due to
its potential therapeutic benefits. However, one of the challenges associated with CBD …

Nanoformulations as a strategy to overcome the delivery limitations of cannabinoids

TS Reddy, R Zomer, N Mantri - Phytotherapy Research, 2023 - Wiley Online Library
Medical cannabis has received significant interest in recent years due to its promising
benefits in the management of pain, anxiety, depression and neurological and movement …

[HTML][HTML] Towards better delivery of cannabidiol (CBD)

SA Millar, RF Maguire, AS Yates, SE O'Sullivan - Pharmaceuticals, 2020 - mdpi.com
Cannabidiol (CBD) has substantial therapeutic potential, but its development as an effective
drug by the pharmaceutical industry is hindered by intrinsic characteristics such as low …

Enhanced Intramuscular Bioavailability of Cannabidiol Using Nanocrystals: Formulation, In Vitro Appraisal, and Pharmacokinetics

X Fu, S Xu, Z Li, K Chen, H Fan, Y Wang, Z Xie… - AAPS …, 2022 - Springer
Cannabidiol (CBD) has poor water solubility and is subjected to extensive first-pass
metabolism. These absorption obstacles are responsible for low and variable oral …

Poly(ethylene glycol)-b-poly(epsilon-caprolactone) nanoparticles as a platform for the improved oral delivery of cannabidiol

I Shreiber-Livne, L Sulimani, A Shapira… - Drug Delivery and …, 2023 - Springer
Abstract Cannabidiol (CBD), a non-psychoactive constituent of Cannabis, has proven
neuroprotective, anti-inflammatory and antioxidant properties though his therapeutic use …

Lipid-based formulations to increase cannabidiol bioavailability: In vitro digestion tests, pre-clinical assessment and clinical trial

MAA De Prá, R Vardanega, CG Loss - International Journal of …, 2021 - Elsevier
Herein, medium-chain triglycerides (MCT), glyceryl monolinoleate (GML), and a self-
emulsifying drug delivery system (SEDDS) for cannabidiol (CBD) delivery were compared …

[HTML][HTML] Development and pharmacokinetic evaluation of a self-nanoemulsifying drug delivery system for the oral delivery of cannabidiol

LY Kok, P Bannigan, F Sanaee, JC Evans… - European Journal of …, 2022 - Elsevier
The number of lipophilic drug candidates in pharmaceutical discovery pipelines has
increased in recent years. These drugs often possess physicochemical properties that result …