Throughout embryonic development, cells undergo a series of lineage decisions,
accompanied by morphological and functional changes, culminating in the formation of a …

Maintenance of pluripotency and specification towards a new cell fate are both dependent
on precise interactions between extrinsic signals and transcriptional and epigenetic …

DNA methylation is an epigenetic mark associated with gene repression, playing a central
role in development as demonstrated by the early lethality of mouse embryos lacking DNA …

DNA methylation is an important epigenetic mark, which is set and maintained by DNA
methyltransferases (Dnmts) and removed via passive or active mechanisms involving Ten …

DNA methylation patterns change dynamically during mammalian development and lineage
specification, yet scarce information is available about how DNA methylation affects gene …

Pluripotency is accompanied by the erasure of parental epigenetic memory, with naïve
pluripotent cells exhibiting global DNA hypomethylation both in vitro and in vivo. Exit from …

In mammals, global DNA demethylation in vivo occurs in the pre-implantation embryo and in
primordial germ cells (PGCs) where it is hypothesized to create a blank slate or 'tabula …

Genome remethylation is essential for mammalian development. Here we examined cell fate
in the absence of de novo DNA methyltransferases. We found that embryonic stem (ES) cells …

Epigenetics is the study of heritable alterations in phenotype caused by changes in cellular
properties, but where the genotype is unchanged. At the molecular level these changes …

Embryonic stem cells have the unique ability to indefinitely self-renew and differentiate into
any cell type found in the adult body. Differentiated cells can, in turn, be reprogrammed to …