Enhancer–promoter contact formation requires RNAPII and antagonizes loop extrusion
Homotypic chromatin interactions and loop extrusion are thought to be the two main drivers
of mammalian chromosome folding. Here we tested the role of RNA polymerase II (RNAPII) …
of mammalian chromosome folding. Here we tested the role of RNA polymerase II (RNAPII) …
Transcription shapes 3D chromatin organization by interacting with loop extrusion
EJ Banigan, W Tang… - Proceedings of the …, 2023 - National Acad Sciences
Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …
RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis
Mammalian chromosomes are three-dimensional entities shaped by converging and
opposing forces. Mitotic cell division induces marked chromosome condensation, but …
opposing forces. Mitotic cell division induces marked chromosome condensation, but …
[HTML][HTML] Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF
A Aljahani, P Hua, MA Karpinska, K Quililan… - Nature …, 2022 - nature.com
Enhancers and promoters predominantly interact within large-scale topologically
associating domains (TADs), which are formed by loop extrusion mediated by cohesin and …
associating domains (TADs), which are formed by loop extrusion mediated by cohesin and …
[HTML][HTML] Gain of CTCF-anchored chromatin loops marks the exit from naive pluripotency
The genome of pluripotent stem cells adopts a unique three-dimensional architecture
featuring weakly condensed heterochromatin and large nucleosome-free regions. Yet, it is …
featuring weakly condensed heterochromatin and large nucleosome-free regions. Yet, it is …
Enhancer hubs and loop collisions identified from single-allele topologies
A Allahyar, C Vermeulen, BAM Bouwman, PHL Krijger… - Nature …, 2018 - nature.com
Chromatin folding contributes to the regulation of genomic processes such as gene activity.
Existing conformation capture methods characterize genome topology through analysis of …
Existing conformation capture methods characterize genome topology through analysis of …
The macro and micro of chromosome conformation capture
The 3D organization of the genome facilitates gene regulation, replication, and repair,
making it a key feature of genomic function and one that remains to be properly understood …
making it a key feature of genomic function and one that remains to be properly understood …
A mechanism of cohesin‐dependent loop extrusion organizes zygotic genome architecture
Fertilization triggers assembly of higher‐order chromatin structure from a condensed
maternal and a naïve paternal genome to generate a totipotent embryo. Chromatin loops …
maternal and a naïve paternal genome to generate a totipotent embryo. Chromatin loops …
[HTML][HTML] Resolving the 3D landscape of transcription-linked mammalian chromatin folding
Whereas folding of genomes at the large scale of epigenomic compartments and
topologically associating domains (TADs) is now relatively well understood, how chromatin …
topologically associating domains (TADs) is now relatively well understood, how chromatin …
New insights into genome folding by loop extrusion from inducible degron technologies
Chromatin folds into dynamic loops that often span hundreds of kilobases and physically
wire distant loci together for gene regulation. These loops are continuously created …
wire distant loci together for gene regulation. These loops are continuously created …