The nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome in the kidney
and the heart is increasingly being suggested to play a key role in mediating inflammation …

Atherosclerosis is a lipid-driven chronic inflammatory disease that is widespread in the walls
of large and medium-sized arteries. Its pathogenesis is not fully understood. The currently …

Highlights•NLRP3 inflammasome activity plays an important role in inflammatory
responses.•NLRP3 inflammasome is also implicated in diabetic nephropathy (DN) …

Diabetes mellitus is an increasingly prevalent disease around the globe. The epidemic of
diabetes mellitus and its complications pretenses the foremost health threat globally …

Diabetic nephropathy (DN) is a serious complication of diabetes mellitus, and persistent
inflammation in circulatory and renal tissues is an important pathophysiological basis for DN …

Bacground Sodium–glucose cotransporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4
inhibitors (DPP4I) are used to treat type 2 diabetes (T2DM). DPP4 inhibitors (DPP4) …

Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular events
in humans with type 2 diabetes (T2D); however, the underlying mechanism remains unclear …

Metabolic dysfunction plays a key role in the development of diabetic nephropathy (DN).
However, the exact effects and mechanisms are still unclear. The pyrin domain‐containing …

The NOD-like receptor protein 3 (NLRP3) inflammasome is a multi-protein signalling
complex integral to the chronic inflammatory response, activated in response to sterile and …

Type 2 diabetes mellitus (T2DM), accounting for 90–95% cases of diabetes, is characterized
by chronic inflammation. The mechanisms that control inflammation activation in T2DM are …